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Current concepts and challenges in osteochondral tissue engineering and regenerative medicine

2015-12-14Journal article Open access
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dc.contributor.authorYan, Le Ping
dc.contributor.authorOliveira, Joaquim M.
dc.contributor.authorOliveira, Ana L.
dc.contributor.authorReis, Rui L.
dc.date.accessioned2021-07-18T15:45:55Z
dc.date.available2021-07-18T15:45:55Z
dc.date.issued2015-12-14
dc.description.abstractIn the past few years, great progress has been made to validate tissue engineering strategies in preclinical studies and clinical trials on the regeneration of osteochondral defects. In the preclinical studies, one of the dominant strategies comprises the development of biomimetic/bioactive scaffolds, which are used alone or incorporated with growth factors and/or stem cells. Many new trends are emerging for modulation of stem cell fate toward osteogenic and chondrogenic differentiations, but bone/cartilage interface regeneration and physical stimulus have been showing great promise. Besides the matrix-associated autologous chondrocyte implantation (MACI) procedure, the matrix-associated stem cell implantation (MASI) and layered scaffolds in acellular or cellular strategy are also applied in clinic. This review outlines the progresses at preclinical and clinical levels, and identifies the new challenges in osteochondral tissue engineering. Future perspectives are provided, e.g., the applications of extracellular matrix-like biomaterials, computer-aided design/manufacture of osteochondral implant, and reprogrammed cells for osteochondral regeneration.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.doi10.1021/ab500038ypt_PT
dc.identifier.eid84969261003
dc.identifier.issn2373-9878
dc.identifier.pmid33435045
dc.identifier.urihttp://hdl.handle.net/10400.14/34160
dc.identifier.wos000369347300001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectBiomimeticpt_PT
dc.subjectClinical trialpt_PT
dc.subjectInterface engineeringpt_PT
dc.subjectLayered scaffoldpt_PT
dc.subjectOsteochondral tissue engineeringpt_PT
dc.subjectPluripotent stem cellspt_PT
dc.titleCurrent concepts and challenges in osteochondral tissue engineering and regenerative medicinept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage200pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage183pt_PT
oaire.citation.titleACS Biomaterials Science and Engineeringpt_PT
oaire.citation.volume1pt_PT
person.familyNameYan
person.familyNameOliveira
person.familyNameOliveira
person.familyNameReis
person.givenNameLeping
person.givenNameJoaquim Miguel
person.givenNameAna
person.givenNameRui L.
person.identifier1568951
person.identifier231614
person.identifier1415634
person.identifier832165
person.identifier.ciencia-idD117-EFAE-39F8
person.identifier.ciencia-id0B16-8EF6-862A
person.identifier.ciencia-id4713-31C8-A356
person.identifier.ciencia-id6F11-C02E-8B6C
person.identifier.orcid0000-0002-4806-5052
person.identifier.orcid0000-0001-7052-8837
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0002-4295-6129
person.identifier.ridA-8622-2013
person.identifier.ridH-8636-2012
person.identifier.ridJ-3404-2013
person.identifier.ridA-8938-2008
person.identifier.scopus-author-id37032413400
person.identifier.scopus-author-id57202066972
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id56861715700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication029c82c6-5d67-4114-80e1-2ec07adb1330
relation.isAuthorOfPublication75809bf3-617b-458b-b055-a40506e3026b
relation.isAuthorOfPublication87934068-f621-402f-b5e6-93e492526ced
relation.isAuthorOfPublication7a393e8e-6f6c-424c-9dda-02100315967b
relation.isAuthorOfPublication.latestForDiscovery029c82c6-5d67-4114-80e1-2ec07adb1330

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