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Evolutionary immunology to explore original antiviral strategies

dc.contributor.authorImler, Jean-Luc
dc.contributor.authorCai, Hua
dc.contributor.authorMeignin, Carine
dc.contributor.authorMartins, Nelson
dc.date.accessioned2024-03-06T10:14:50Z
dc.date.available2024-03-06T10:14:50Z
dc.date.issued2023-12-18
dc.description.abstractOver the past 25 years, the field of evolutionary developmental biology (evo-devo) has used genomics and genetics to gain insight on the developmental mechanisms underlying the evolution of morphological diversity of animals. Evo-devo exploits the key insight that conserved toolkits of development (e.g., Hox genes) are used in animals to produce genetic novelties that provide adaptation to a new environment. Like development, immunity is forged by interactions with the environment, namely the microbial world. Yet, when it comes to the study of immune defence mechanisms in invertebrates, interest primarily focuses on evolutionarily conserved molecules also present in humans. Here, focusing on antiviral immunity, we argue that immune genes not conserved in humans represent an unexplored resource for the discovery of new antiviral strategies. We review recent findings on the cGAS-STING pathway and explain how cyclic dinucleotides produced by cGAS-like receptors may be used to investigate the portfolio of antiviral genes in a broad range of species. This will set the stage for evo-immuno approaches, exploiting the investment in antiviral defences made by metazoans over hundreds million years of evolution.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.32942/x2dw4tpt_PT
dc.identifier.urihttp://hdl.handle.net/10400.14/44131
dc.language.isoengpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInnate immunitypt_PT
dc.subjectSTINGpt_PT
dc.subjectCyclic dinucleotidept_PT
dc.subjectcGASpt_PT
dc.subjectCBASSpt_PT
dc.titleEvolutionary immunology to explore original antiviral strategiespt_PT
dc.typeworking paper
dspace.entity.typePublication
rcaap.rightsopenAccesspt_PT
rcaap.typeworkingPaperpt_PT

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