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Polyphenols: a promising avenue in therapeutic solutions for wound care

2021-02-01Artigo científico Acesso aberto
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dc.contributor.authorGuimarães, Inês
dc.contributor.authorBaptista-Silva, Sara
dc.contributor.authorPintado, Manuela
dc.contributor.authorOliveira, Ana L.
dc.date.accessioned2021-03-29T18:20:37Z
dc.date.available2021-03-29T18:20:37Z
dc.date.issued2021-02-01
dc.description.abstractIn chronic wounds, the regeneration process is compromised, which brings complexity to the therapeutic approaches that need to be adopted, while representing an enormous loss in the patients’ quality of life with consequent economical costs. Chronic wounds are highly prone to infection, which can ultimately lead to septicemia and morbidity. Classic therapies are increasing antibiotic resistance, which is becoming a critical problem beyond complex wounds. Therefore, it is essential to study new antimicrobial polymeric systems and compounds that can be effective alternatives to reduce infection, even at lower concentrations. The biological potential of polyphenols allows them to be an efficient alternative to commercial antibiotics, responding to the need to find new options for chronic wound care. Nonetheless, phenolic compounds may have some drawbacks when targeting wound applications, such as low stability and consequent decreased biological performance at the wound site. To overcome these limitations, polymeric-based systems have been developed as carriers of polyphenols for wound healing, improving its stability, controlling the release kinetics, and therefore increasing the performance and effectiveness. This review aims to highlight possible smart and bio-based wound dressings, providing an overview of the biological potential of polyphenolic agents as natural antimicrobial agents and strategies to stabilize and deliver them in the treatment of complex wounds. Polymer-based particulate systems are highlighted here due to their impact as carriers to increase polyphenols bioavailability at the wound site in different types of formulations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/app11031230pt_PT
dc.identifier.eid85100565561
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.14/32359
dc.identifier.wos000615076200001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInfectionpt_PT
dc.subjectNano/microencapsulationpt_PT
dc.subjectPolymerpt_PT
dc.subjectPolyphenolspt_PT
dc.subjectWound healing and regenerationpt_PT
dc.titlePolyphenols: a promising avenue in therapeutic solutions for wound carept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage20pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleApplied Sciences (Switzerland)pt_PT
oaire.citation.volume11pt_PT
person.familyNameBaptista da Silva
person.familyNamePintado
person.givenNameSara
person.givenNameMaria Manuela
person.identifier404100
person.identifier456608
person.identifier.ciencia-idC510-41A8-08DC
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-1805-144X
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id50060987900
person.identifier.scopus-author-id7004483898
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication404465f0-f877-416f-8259-a3800428580d
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc

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