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Allergic inflammation triggers dyslipidemia via IgG signalling

2023-08-06Working paper Open access
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dc.contributor.authorFernández-Gallego, Nieves
dc.contributor.authorCastillo-González, Raquel
dc.contributor.authorMoreno-Serna, Lucía
dc.contributor.authorGarcía-Cívico, Antonio J.
dc.contributor.authorSánchez-Martínez, Elisa
dc.contributor.authorLópez-Sanz, Celia
dc.contributor.authorFontes, Ana Luiza
dc.contributor.authorPimentel, Lígia L.
dc.contributor.authorGradillas, Ana
dc.contributor.authorObeso, David
dc.contributor.authorRamírez-Huesca, Marta
dc.contributor.authorRuiz-Fernández, Ignacio
dc.contributor.authorNuñez-Borque, Emilio
dc.contributor.authorCarrasco, Yolanda R.
dc.contributor.authorIbáñez, Borja
dc.contributor.authorMartín, Pilar
dc.contributor.authorBlanco, Carlos
dc.contributor.authorBarbas, Coral
dc.contributor.authorBarber, Domingo
dc.contributor.authorRodríguez-Alcalá, Luis M.
dc.contributor.authorVillaseñor, Alma
dc.contributor.authorEsteban, Vanesa
dc.contributor.authorSánchez-Madrid, Francisco
dc.contributor.authorJiménez-Saiz, Rodrigo
dc.date.accessioned2024-03-20T16:42:15Z
dc.date.available2024-03-20T16:42:15Z
dc.date.issued2023-08-06
dc.description.abstractAllergic diseases begin early in life and are often chronic, thus creating an inflammatory environment that may lead to metabolic disorders, although the underlying mechanisms remain incompletely understood. Here, we show that allergic inflammation induces diet-independent dyslipidemia in a mouse model of allergy and atherosclerosis. Using untargeted lipidomics in mouse plasma, we found that allergic inflammation induces a unique lipid signature that extends beyond acute and late inflammation and that is characterized by triglyceride (TG) changes in circulation. Alterations in blood TGs following an allergic reaction are independent of T-cell-driven late phase inflammation. On the contrary, the humoral component is sufficient to induce a TG increase and a unique lipid profile through the IgG-mediated alternative pathway of anaphylaxis. Lastly, we demonstrated blood TG changes in patients after undergoing an allergic reaction. Overall, this study reveals the importance of IgG-mediated allergic inflammation insofar as it regulates lipid metabolism, which may contribute to atherosclerosis and, ultimately, to cardiovascular events.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1101/2023.08.04.551996pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.14/44370
dc.language.isoengpt_PT
dc.publisherbioRxiv'spt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.titleAllergic inflammation triggers dyslipidemia via IgG signallingpt_PT
dc.typeworking paper
dspace.entity.typePublication
oaire.citation.endPage35pt_PT
oaire.citation.startPage1pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeworkingPaperpt_PT

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