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Hydrogels containing porphyrin-loaded nanoparticles for topical photodynamic applications

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dc.contributor.authorGonzález-Delgado, José A.
dc.contributor.authorCastro, Pedro M.
dc.contributor.authorMachado, Alexandra
dc.contributor.authorAraújo, Francisca
dc.contributor.authorRodrigues, Francisca
dc.contributor.authorKorsak, Bárbara
dc.contributor.authorFerreira, Marta
dc.contributor.authorTomé, João P.C.
dc.contributor.authorSarmento, Bruno
dc.date.accessioned2017-10-17T13:41:24Z
dc.date.available2017-10-17T13:41:24Z
dc.date.issued2016
dc.description.abstract5,10,15,20-tetrakis(1-methylpyridinium-4-yl)-porphyrin tetra-iodide (TMPyP), a potent water-soluble photosensitizer (PS) used in antimicrobial applications, was encapsulated into poly(lactic-co-glycolic acid) (PLGA) nanoparticles (TMPyP-PLGA) for topical delivery purposes. Nanoparticles resulted in a mean particle size around 130nm, narrow polydispersity index (PdI), spherical morphology and association efficiency up to 93%. Free TMPyP and TMPyP-PLGA nanoparticles were incorporated into Carbopol(®) hydrogels, resulting in controlled TMPyP release of about 60% and 20% after 4.5h, respectively. Critical properties such as appearance, clarity, viscosity and pH were maintained over time, as hydrogels were stable during 6 months at 4°C, 25°C/60% RH and 40°C/75% RH. For photodynamic applications, the photoproduction of singlet oxygen from these hydrogels was quite efficient being both formulations very photostable after 20min. No TMPyP permeation through pig ear skin was observed after 24h, and histological assays did not show relevant damages in surrounding tissues. All these excellent characteristics make them promising platforms for photodynamic applications through topical clinical use.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGONZÁLEZ-DELGADO, José A.; CASTRO, Pedro M.; MACHADO, Alexandra; ARAÚJO, Francisca; RODRIGUES, Francisca; KORSAK, Bárbara; FERREIRA, Marta; TOMÉ, João P.C.; SARMENTO, Bruno - Hydrogels containing porphyrin-loaded nanoparticles for topical photodynamic applications. International Journal of Pharmaceutics. ISSN 0378-5173. Vol. 510 (2016), p. 221-231pt_PT
dc.identifier.doi10.1016/j.ijpharm.2016.06.037pt_PT
dc.identifier.eid84976426703
dc.identifier.pmid27321129
dc.identifier.urihttp://hdl.handle.net/10400.14/23149
dc.identifier.wos000380754300022
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationFCOMP-01-0124-FEDER-037296pt_PT
dc.relationFP7-PEOPLE-2012-ITNpt_PT
dc.relationStrategic Project - LA 2 - 2013-2014
dc.subjectAdministration, Topicalpt_PT
dc.subjectAnimalspt_PT
dc.subjectHydrogelspt_PT
dc.subjectNanoparticlespt_PT
dc.subjectPhotosensitizing Agentspt_PT
dc.subjectPorphyrinspt_PT
dc.subjectSwinept_PT
dc.titleHydrogels containing porphyrin-loaded nanoparticles for topical photodynamic applicationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 2 - 2013-2014
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PEst-C%2FQUI%2FUI0062%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6820 - DCRRNI ID/PEst-C%2FSAU%2FLA0002%2F2013/PT
oaire.citation.endPage231
oaire.citation.startPage221
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume510
oaire.fundingStreamCOMPETE
oaire.fundingStream6820 - DCRRNI ID
person.familyNameGonzalez-Delgado
person.familyNameMiranda de Castro
person.familyNameMachado
person.familyNameAraújo
person.familyNameRodrigues
person.familyNameTome
person.familyNameSarmento
person.givenNameJose Antonio
person.givenNamePedro João
person.givenNameAlexandra
person.givenNameFrancisca
person.givenNameFrancisca
person.givenNameJoao
person.givenNameBruno
person.identifier404098
person.identifier152609
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person.identifier.ciencia-id9615-B523-42BB
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.orcid0000-0003-3636-9240
person.identifier.orcid0000-0001-7164-8005
person.identifier.orcid0000-0002-9347-2407
person.identifier.orcid0000-0001-9087-9941
person.identifier.orcid0000-0001-8803-0041
person.identifier.orcid0000-0001-6057-4936
person.identifier.orcid0000-0001-5763-7553
person.identifier.ridJ-8543-2013
person.identifier.ridK-9099-2017
person.identifier.ridK-6782-2014
person.identifier.ridJ-6265-2013
person.identifier.scopus-author-id37112175300
person.identifier.scopus-author-id57201808340
person.identifier.scopus-author-id56516107400
person.identifier.scopus-author-id43961072500
person.identifier.scopus-author-id55236983800
person.identifier.scopus-author-id7004822889
person.identifier.scopus-author-id57194334236
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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