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Carotenoids and intestinal harmony: exploring the link for health

2024-06Journal article Open access
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dc.contributor.authorRocha, Helena R.
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorGomes, Ana M.
dc.contributor.authorCoelho, Marta C.
dc.date.accessioned2024-06-25T09:57:07Z
dc.date.available2024-06-25T09:57:07Z
dc.date.issued2024-06
dc.description.abstractCarotenoids, prominent lipid-soluble phytochemicals in the human diet, are responsible for vibrant colours in nature and play crucial roles in human health. While they are extensively studied for their antioxidant properties and contributions to vitamin A synthesis, their interactions with the intestinal microbiota (IM) remain poorly understood. In this study, beta (β)-carotene, lutein, lycopene, a mixture of these three pigments, and the alga Osmundea pinnatifida were submitted to simulated gastrointestinal digestion (GID) and evaluated on human faecal samples. The results showed varying effects on IM metabolic dynamics, organic acid production, and microbial composition. Carotenoid exposure influenced glucose metabolism and induced the production of organic acids, notably succinic and acetic acids, compared with the control. Microbial composition analysis revealed shifts in phyla abundance, particularly increased Pseudomonadota. The α-diversity indices demonstrated higher diversity in β-carotene and the pigments’ mixture samples, while the β-diversity analysis indicated significant dissimilarity between the control and the carotenoid sample groups. UPLC-qTOF MS analysis suggested dynamic changes in carotenoid compounds during simulated fermentation, with lutein exhibiting distinct mass ion fragmentation patterns. This comprehensive research enhances our understanding of carotenoid-IM interactions, shedding light on potential health implications and the need for tailored interventions for optimal outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/foods13111599pt_PT
dc.identifier.eid85195851814
dc.identifier.issn2304-8158
dc.identifier.pmcPMC11171705
dc.identifier.pmid38890828
dc.identifier.urihttp://hdl.handle.net/10400.14/45593
dc.identifier.wos001245379000001
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFermentationpt_PT
dc.subjectIntestinal microbiotapt_PT
dc.subjectMetabolitespt_PT
dc.subjectModulationpt_PT
dc.subjectNatural pigmentspt_PT
dc.titleCarotenoids and intestinal harmony: exploring the link for healthpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.titleFoodspt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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