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Antinociceptive and anti-inflammatory effects of novel dietary protein hydrolysate produced from whey by proteases of Cynara cardunculus

2013Journal article Restricted access
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dc.contributor.authorTavares, T. G.
dc.contributor.authorSpindola, H.
dc.contributor.authorLongato, G.
dc.contributor.authorPintado, M. E.
dc.contributor.authorCarvalho, J. E.
dc.contributor.authorMalcata, F. X.
dc.date.accessioned2014-05-15T11:51:21Z
dc.date.available2014-05-15T11:51:21Z
dc.date.issued2013
dc.description.abstractAntinociceptive and anti-inflammatory effects of a peptide concentrate mix (PepC) obtained from whey protein, via hydrolysis with cardosins from Cynara cardunculus, was tested in vivo. The antinociceptive effect was assessed using writhing, hot-plate and formalin tests in mice, and the anti-inflammatory effect using the paw oedema test. PepC at 300 mg kg(-1) bw conveyed a significant result in the writhing test when co-administered with 1 and 3 mg kg(-1) bw indomethacin, similar to administration of higher doses of indomethacin alone. Conversely, no statistically significant differences were observed in the paw oedema test when the same PepC concentration was co-administered with dexamethasone at 3, 10 and 30 mg kg(-1) bw. PepC at 1000 mg kg(-1) bw did not cause any remarkable outcome in the hot-plate test. PepC appears to possess anti-inflammatory and peripheral antinociceptive activities, so it may be a candidate for nutraceutical ingredient.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationTAVARES, T. G… [et al.] - Antinociceptive and anti-inflammatory effects of novel dietary protein hydrolysate produced from whey by proteases of Cynara cardunculus. International Dairy Journal. ISSN 0958-6946. Vol. 32, n.º 2 (2013), p. 156-162por
dc.identifier.doi10.1016/j.idairyj.2013.05.010
dc.identifier.eissn1879-0143
dc.identifier.issn0958-6946
dc.identifier.urihttp://hdl.handle.net/10400.14/14424
dc.identifier.wosWOS:000321744300015
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.titleAntinociceptive and anti-inflammatory effects of novel dietary protein hydrolysate produced from whey by proteases of Cynara cardunculuspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117658%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F31604%2F2006/PT
oaire.citation.endPage162
oaire.citation.issue2
oaire.citation.startPage156
oaire.citation.titleInternational Dairy Journal
oaire.citation.volume32
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
person.familyNameGranja Tavares
person.familyNamePintado
person.familyNameMalcata
person.givenNameTânia Sofia
person.givenNameMaria Manuela
person.givenNameFrancisco
person.identifier456608
person.identifier.ciencia-idDB16-AFE8-27BD
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-id1B13-38A5-35F5
person.identifier.orcid0000-0002-6329-0602
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0003-3073-1659
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id7003730119
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id7102542478
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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