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Bioadhesive polymeric nanoparticles as strategy to improve the treatment of yeast infections in oral cavity: in-vitro and ex-vivo studies

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dc.contributor.authorRoque, Luís
dc.contributor.authorCastro, Pedro
dc.contributor.authorMolpeceres, Jesus
dc.contributor.authorViana, Ana S.
dc.contributor.authorRoberto, Amilcar
dc.contributor.authorReis, Claúdia
dc.contributor.authorRijo, Patrícia
dc.contributor.authorTho, Ingunn
dc.contributor.authorSarmento, Bruno
dc.contributor.authorReis, Catarina
dc.date.accessioned2018-10-23T17:50:10Z
dc.date.available2018-10-23T17:50:10Z
dc.date.issued2018
dc.description.abstractCandidiasis is by far the most common fungal infection in the oral cavity and locally antifungal drugs are generally considered the first line therapy. However, some antifungal drugs like Nystatin (Nys) have very short time in the target tissue, which generally it requires several daily applications. One of the solutions to overcome those issues could be the incorporation of Nys into small, protective and polymeric nanoparticles (NPs). In this work, unloaded NPs were prepared and fully characterized and implemented in toothpaste and an oral gel. The three-best unloaded system (smallest, stable, safe and bioadhesive) was selected for further studies. After loading, NPs presented a size range from 300 to 800 nm, high encapsulation efficiency (above 70%), prolonged release and high adhesion capacity to oral mucosa when compared with free Nys. Free Nys lost its activity when it was not encapsulated. The presented results suggested that these new bioadhesive systems could be considered as good candidates to improve the time residence of Nys in buccal mucosa, reducing the number of applications during the day, using alcohol free-formulations and easily included in the daily lives of the patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRoque, L., Castro, P., Molpeceres, J., Viana, A.S., Roberto, A., Reis, … Reis, C. (2018). Bioadhesive polymeric nanoparticles as strategy to improve the treatment of yeast infections in oral cavity: in-vitro and ex-vivo studies. European Polymer Journal, 104, 19-31pt_PT
dc.identifier.doi10.1016/j.eurpolymj.2018.04.032pt_PT
dc.identifier.eid85046657641
dc.identifier.eissn1873-1945
dc.identifier.issn0014-3057
dc.identifier.urihttp://hdl.handle.net/10400.14/25824
dc.identifier.wos000436886800003
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectPolymeric nanoparticlespt_PT
dc.subjectAntifungal drugpt_PT
dc.subjectBioadhesionpt_PT
dc.subjectOral mucosa deliverypt_PT
dc.subjectIn vitro and ex-vivo studiespt_PT
dc.titleBioadhesive polymeric nanoparticles as strategy to improve the treatment of yeast infections in oral cavity: in-vitro and ex-vivo studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage31
oaire.citation.startPage19
oaire.citation.titleEuropean Polymer Journalpt_PT
oaire.citation.volume104
person.familyNameMiranda de Castro
person.familyNameTho
person.familyNameSarmento
person.familyNameReis
person.givenNamePedro João
person.givenNameIngunn
person.givenNameBruno
person.givenNameCatarina
person.identifier152609
person.identifier643639
person.identifier.ciencia-id5112-6B99-DC1F
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.ciencia-id1317-A7D6-3B1C
person.identifier.orcid0000-0001-7164-8005
person.identifier.orcid0000-0003-4241-4183
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0002-1046-4031
person.identifier.ridJ-6265-2013
person.identifier.ridM-8132-2013
person.identifier.scopus-author-id57201808340
person.identifier.scopus-author-id6602467586
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id14027161300
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication99909754-7408-4e67-8f02-9cdb3c5a88d4
relation.isAuthorOfPublication63c95f00-f05a-43b4-8185-f852bf56ad26
relation.isAuthorOfPublication1df2ac4c-2a82-4f3b-9aea-6f4fb9964752
relation.isAuthorOfPublicationdac3c9be-2133-4b7e-b01c-97c75b36a52d
relation.isAuthorOfPublication.latestForDiscoverydac3c9be-2133-4b7e-b01c-97c75b36a52d

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