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Advisor(s)
Abstract(s)
The relationship between antimicrobial residues, antibiotic resistance prevalence and
bacterial community composition in hospital effluent and in the receiving wastewater
treatment plant was studied. Samples from hospital effluent, raw inflow and final effluent
of the receiving wastewater treatment plant were characterized for amoxicillin and ciprofloxacin
resistance prevalence, content of heavy metals and antimicrobial residues and
bacterial community structure, based on 16S rRNA gene PCR-DGGE analysis. The concentration
of fluoroquinolones, arsenic and mercury was in general higher in hospital effluent
than in raw inflow, while the opposite was observed for tetracyclines, sulfonamides and
penicillin G. The prevalence of ciprofloxacin resistance was significantly higher in hospital
effluent than in raw inflow. The concentration of antimicrobial residues was observed to be
significantly correlated with the prevalence of antibiotic resistant bacteria and with variations
in the bacterial community. Hospital effluent was confirmed as a relevant, although
not unique, source of antimicrobial residues and antibiotic resistant bacteria to the
wastewater treatment plant. Moreover, given the high loads of antibiotic residues and
antibiotic resistant bacteria that may occur in hospital effluents, these wastewater habitats
may represent useful models to study and predict the impact of antibiotic residues on
bacterial communities.
Description
Keywords
Wastewater Hospital effluents Antimicrobial residues Antibiotic resistance Bacterial communities
Citation
VARELA, Ana Rita [et al.] - Insights into the relationship between antimicrobial residues and bacterial populations in a hospital-urban wastewater treatment plant system. Water research. ISSN 0043-1354. Vol. 54 (2014), p. 327-336
Publisher
Elsevier