Publicação
Lavandula pedunculata polyphenol-rich extracts obtained by conventional, MAE and UAE methods: exploring the bioactive potential and safety for use a medicine plant as food and nutraceutical ingredient
| dc.contributor.author | Vilas-Boas, Ana A. | |
| dc.contributor.author | Goméz-García, Ricardo | |
| dc.contributor.author | Machado, Manuela | |
| dc.contributor.author | Nunes, Catarina | |
| dc.contributor.author | Ribeiro, Sónia | |
| dc.contributor.author | Nunes, João | |
| dc.contributor.author | Oliveira, Ana L. S. | |
| dc.contributor.author | Pintado, Manuela | |
| dc.date.accessioned | 2024-01-30T19:26:42Z | |
| dc.date.available | 2024-01-30T19:26:42Z | |
| dc.date.issued | 2023-12 | |
| dc.description.abstract | Nowadays, plant-based bioactive compounds (BCs) are a key focus of research, supporting sustainable food production and favored by consumers for their perceived safety and health advantages over synthetic options. Lavandula pedunculata (LP) is a Portuguese, native species relevant to the bioeconomy that can be useful as a source of natural BCs, mainly phenolic compounds. This study compared LP polyphenol-rich extracts from conventional maceration extraction (CE), microwave and ultrasound-assisted extraction (MAE and UAE). As a result, rosmarinic acid (58.68–48.27 mg/g DE) and salvianolic acid B (43.19–40.09 mg/g DE) were the most representative phenolic compounds in the LP extracts. The three methods exhibited high antioxidant activity, highlighting the ORAC (1306.0 to 1765.5 mg Trolox equivalents (TE)/g DE) results. In addition, the extracts obtained with MAE and CE showed outstanding growth inhibition for B. cereus, S. aureus, E. coli, S. enterica and P. aeruginosa (>50%, at 10 mg/mL). The MAE extract showed the lowest IC50 (0.98 mg DE/mL) for angiotensin-converting enzyme inhibition and the best results for α-glucosidase and tyrosinase inhibition (at 5 mg/mL, the inhibition was 87 and 73%, respectively). The LP polyphenol-rich extracts were also safe on caco-2 intestinal cells, and no mutagenicity was detected. The UAE had lower efficiency in obtaining LP polyphenol-rich extracts. MAE equaled CE’s efficiency, saving time and energy. LP shows potential as a sustainable raw material, allowing diverse extraction methods to safely develop health-promoting food and nutraceutical ingredients. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.3390/foods12244462 | pt_PT |
| dc.identifier.eid | 85180711023 | |
| dc.identifier.issn | 2304-8158 | |
| dc.identifier.pmc | PMC10742868 | |
| dc.identifier.pmid | 38137266 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/43778 | |
| dc.identifier.wos | 001132329100001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Food additive | pt_PT |
| dc.subject | Lavandula pedunculata | pt_PT |
| dc.subject | Microwave-assisted extraction | pt_PT |
| dc.subject | Nutraceutical | pt_PT |
| dc.subject | Phenolic compounds | pt_PT |
| dc.subject | Rosmarinic acid | pt_PT |
| dc.subject | Ultrasound-assisted extraction | pt_PT |
| dc.title | Lavandula pedunculata polyphenol-rich extracts obtained by conventional, MAE and UAE methods: exploring the bioactive potential and safety for use a medicine plant as food and nutraceutical ingredient | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 24 | pt_PT |
| oaire.citation.title | Foods | pt_PT |
| oaire.citation.volume | 12 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |