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Ofloxacin determination in urine, serum and pharmaceuticals using an automatic flow potentiometric system

2013Journal article Open access
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dc.contributor.authorPimenta, Adriana M.
dc.contributor.authorSouto, M. Renata S.
dc.contributor.authorCatarino, Rita I. L.
dc.contributor.authorLeal, M. Fernanda C.
dc.contributor.authorLima, José L. F. Costa
dc.date.accessioned2021-07-06T19:38:23Z
dc.date.available2021-07-06T19:38:23Z
dc.date.issued2013
dc.description.abstractAn automatic system was developed to determine ofloxacin in biological fluids and pharmaceutical formulations. Drug detection was carried out by a potentiometric membrane sensor based on [bis(trifluoromethyl)phenyl]borate as molecular-recognition material. The tubular shaped detector system was solidly attached to the manifold, creating a high-throughput stable setup (50 samples per hour) appropriate for routine antibiotic assessment. Under the optimized flow conditions, the sensor displayed a mean detection limit of 1 × 10 -5 M, a linear response over the concentrations of 2 × 10 -5 to 5 × 10 -3 M (slope of 57.4 mV decade -1 ) and a wide working pH range (2.1-6.6). The procedure was successfully applied to ofloxacin analysis in pharmaceuticals (relative deviation lower than 6%) and biological fluids at levels usually found after drug administration of clinical doses (recoveries between 91 and 106%). No significant interference from common excipients found in commercial formulations and inorganic ions usually present in biological fluids was noticed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.2116/analsci.29.893pt_PT
dc.identifier.eid84884934181
dc.identifier.issn0910-6340
dc.identifier.pmid24025573
dc.identifier.urihttp://hdl.handle.net/10400.14/34101
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAutomatic determinationpt_PT
dc.subjectOfloxacinpt_PT
dc.subjectPharmaceuticalspt_PT
dc.subjectSerumpt_PT
dc.subjectUrinept_PT
dc.titleOfloxacin determination in urine, serum and pharmaceuticals using an automatic flow potentiometric systempt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage898pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage893pt_PT
oaire.citation.titleAnalytical Sciencespt_PT
oaire.citation.volume29pt_PT
person.familyNamePimenta
person.familyNameSouto
person.familyNameCatarino
person.familyNameLeal
person.familyNameLima
person.givenNameAdriana
person.givenNameRenata
person.givenNameRita
person.givenNameFernanda
person.givenNameJosé
person.identifierR-000-8FJ
person.identifier.ciencia-id211D-C53A-B059
person.identifier.ciencia-id9814-DF91-15FA
person.identifier.ciencia-idB517-2F1F-F2E4
person.identifier.ciencia-id5916-B87F-2482
person.identifier.ciencia-id4811-9AA9-D673
person.identifier.orcid0000-0003-1975-5094
person.identifier.orcid0000-0002-2130-8667
person.identifier.orcid0000-0001-9010-2921
person.identifier.orcid0000-0002-0118-9007
person.identifier.orcid0000-0002-8906-9826
person.identifier.ridD-6248-2013
person.identifier.ridM-7017-2013
person.identifier.ridD-6597-2013
person.identifier.ridD-6188-2013
person.identifier.scopus-author-id36841737900
person.identifier.scopus-author-id7005270435
person.identifier.scopus-author-id6603283442
person.identifier.scopus-author-id7101675251
person.identifier.scopus-author-id10141079100
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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