Publication
The pro- and anti-inflammatory activity of fatty acids
| dc.contributor.author | Salsinha, Ana Sofia | |
| dc.contributor.author | Socodato, Renato | |
| dc.contributor.author | Relvas, João B. | |
| dc.contributor.author | Pintado, Manuela | |
| dc.date.accessioned | 2022-10-13T16:43:02Z | |
| dc.date.available | 2022-10-13T16:43:02Z | |
| dc.date.issued | 2022-01-01 | |
| dc.description.abstract | Inflammation is crucial to maintain homeostasis in the body. The contribution of fatty acids to the inflammatory process is exerted through a variety of mechanisms leading to cell surface modifications, activation of intracellular receptors that control inflammatory signaling processes, and changes in gene expression patterns. While long-chain saturated fatty acids induce NFkB pathway activation through TLR-4 binding, unsaturated fatty acids, such as monounsaturated, polyunsaturated, and conjugated fatty acids’ antiinflammatory ability is mediated through PPARs or GPR120. Moreover, these unsaturated fatty acids, especially omega-3 fatty acids, have immunomodulatory and cytoprotective potential, which is highly relevant for diseases with a neuroinflammatory component, such as obesity, Alzheimer’s disease, multiple sclerosis, and schizophrenia. | pt_PT |
| dc.description.version | info:eu-repo/semantics/acceptedVersion | pt_PT |
| dc.identifier.doi | 10.1016/B978-0-12-824043-4.00002-6 | pt_PT |
| dc.identifier.eid | 85161949107 | |
| dc.identifier.isbn | 9780128240434 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/39130 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Academic Press | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | pt_PT |
| dc.subject | Bioactive lipids | pt_PT |
| dc.subject | Fatty acids | pt_PT |
| dc.subject | Pro-inflammatory | pt_PT |
| dc.subject | Anti-inflammatory | pt_PT |
| dc.subject | Neuroinflammation | pt_PT |
| dc.subject | Omega-3 | pt_PT |
| dc.title | The pro- and anti-inflammatory activity of fatty acids | pt_PT |
| dc.type | book part | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Cambridge | pt_PT |
| oaire.citation.endPage | 75 | pt_PT |
| oaire.citation.startPage | 51 | pt_PT |
| oaire.citation.title | Bioactive lipids | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | bookPart | pt_PT |