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Influence of abiotic factors on the antimicrobial activity of chitosan

2013Journal article Restricted access
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dc.contributor.authorTavaria, Freni K.
dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorGens, Eduardo J.
dc.contributor.authorMalcata, Francisco Xavier
dc.contributor.authorPintado, Manuela E.
dc.date.accessioned2014-05-08T10:42:58Z
dc.date.available2014-05-08T10:42:58Z
dc.date.issued2013
dc.description.abstractIn an effort to bypass the adverse secondary effects attributed to the traditional therapeutic approaches used to treat skin disorders (such as atopic dermatitis), alternative antimicrobials have recently been suggested. One such antimicrobial is chitosan, owing to the already proved biological properties associated with its use. However, the influence of abiotic factors on such activities warrants evaluation. This research effort assessed the antimicrobial activity of chitosan upon skin microorganisms (Staphylococcus aureus, Staphylococcus epidermidis and Escherichia coli) in vitro when subject to a combination of different abiotic factors such as pH, ionic strength, organic acids and free fatty acids. Free fatty acids, ionic strength and pH significantly affected chitosan's capability of reducing the viable numbers of S.aureus. This antimicrobial action was potentiated in the presence of palmitic acid and a lower ionic strength (0.2% NaCl), while a higher ionic strength (0.4% NaCl) favored chitosan's action upon the reduction of viable numbers of S.epidermidis and E.coli. Although further studies are needed, these preliminary results advocate that chitosan can in the future be potentially considered as an antimicrobial of choice when handling symptoms associated with atopic dermatitis.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationTAVARIA, Freni ...[et al.] - Influence of abiotic factors on the antimicrobial activity of chitosan. The Journal of Dermatology . ISSN 1346-8138 . Vol. 40 (2013), p. 1014–1019por
dc.identifier.doi10.1111/1346-8138.12315
dc.identifier.eissn1346-8138
dc.identifier.issn0385-2407
dc.identifier.urihttp://hdl.handle.net/10400.14/14287
dc.identifier.wosWOS:000328398400012
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.relationSI IDT 2008/1448
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectAntibacterial activitypor
dc.subjectAtopic dermatitispor
dc.subjectChitosanpor
dc.subjectSkin pathogenspor
dc.subjectStaphylococcus aureuspor
dc.titleInfluence of abiotic factors on the antimicrobial activity of chitosanpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F24222%2F2005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FCTM%2F58312%2F2004/PT
oaire.citation.endPage1019
oaire.citation.issue12
oaire.citation.startPage1014
oaire.citation.titleJournal of Dermatology
oaire.citation.volume40
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
oaire.fundingStreamPOCI
person.familyNameKekhasharú Tavaria
person.familyNameCosta
person.familyNameMalcata
person.familyNamePintado
person.givenNameFreni
person.givenNameEduardo
person.givenNameFrancisco
person.givenNameMaria Manuela
person.identifier456608
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id1B13-38A5-35F5
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0003-3073-1659
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id7102542478
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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