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Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus

2011Journal article Restricted access
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dc.contributor.authorTavares, T.G.
dc.contributor.authorMonteiro, K.M.
dc.contributor.authorPossenti, A.
dc.contributor.authorPintado, M. E.
dc.contributor.authorCarvalho, J. E.
dc.contributor.authorMalcata, F. Xavier
dc.date.accessioned2012-02-27T16:24:43Z
dc.date.available2012-02-27T16:24:43Z
dc.date.issued2011
dc.description.abstractPeptide concentrates generated by hydrolysis of whey with aqueous extracts of flowers of Cynara cardunculus were studied for possible protection of the stomach mucosa against ulcerative lesions caused by oral administration of absolute ethanol. Both the whole peptide fraction obtained via hydrolysis of whey protein concentrate (peptide concentrate, PepC) and its fraction below 3 kDa (PepCF) were able to reduce gastric injuries to significant levels (p < 0.05). Single-dose experiments, using 100 mg kg(-1) body weight (bw) of either PepCF or PepC, led to 68.5% and 37.4% protection, respectively - which compare well with 93.4% protection by 200 mg kg (1) bw carbenoxolone (a positive control). No dose-response correlation could be demonstrated. Gastric cytoprotection by PepCF appears to depend on sulphydryl-containing moieties, whereas PepC likely protects the gastric mucosa via the prostaglandin cycle and production of nitric oxide.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationTAVARES, T.G... [et al.] - Antiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculus. International Dairy Journal. ISSN 0958-6946. Vol. 21, n.º 12 (2011), p.934–939por
dc.identifier.doi10.1016/j.idairyj.2011.06.004
dc.identifier.eissn1879-0143
dc.identifier.issn0958-6946
dc.identifier.urihttp://hdl.handle.net/10400.14/7965
dc.identifier.wosWOS:000295830900005
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.titleAntiulcerogenic activity of peptide concentrates obtained from hydrolysis of whey proteins by proteases from Cynara cardunculuspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F31604%2F2006/PT
oaire.citation.endPage939
oaire.citation.issue12
oaire.citation.startPage934
oaire.citation.titleInternational Dairy Journal
oaire.citation.volume21
oaire.fundingStreamSFRH
person.familyNameGranja Tavares
person.familyNameMonteiro
person.familyNamePintado
person.familyNameMalcata
person.givenNameTânia Sofia
person.givenNameKarin
person.givenNameMaria Manuela
person.givenNameFrancisco
person.identifier456608
person.identifier.ciencia-idDB16-AFE8-27BD
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-id1B13-38A5-35F5
person.identifier.orcid0000-0002-6329-0602
person.identifier.orcid0000-0003-0681-4956
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0003-3073-1659
person.identifier.ridY-2462-2018
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id7003730119
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id7102542478
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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