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Fructooligosaccharides enhance the gut–liver effects of raspberry polyphenols in a rat model of diet-induced metabolic dysfunction-associated steatotic liver disease

2026-10-01Artigo de investigação Acesso aberto
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dc.contributor.authorFotschki, Bartosz
dc.contributor.authorKopcewicz, Marta
dc.contributor.authorFotschki, Joanna
dc.contributor.authorMachcińska-Zielińska, Sylwia
dc.contributor.authorSłowińska, Mariola
dc.contributor.authorSawicki, Tomasz
dc.contributor.authorWiczkowski, Wiesław
dc.contributor.authorSójka, Michał
dc.contributor.authorJanda, Elżbieta
dc.contributor.authorOgnik, Katarzyna
dc.contributor.authorJurgoński, Adam
dc.contributor.authorSilva, Sara
dc.contributor.authorJuśkiewicz, Jerzy
dc.date.accessioned2026-07-30T15:47:22Z
dc.date.available2026-07-30T15:47:22Z
dc.date.issued2026-10-01
dc.description.abstractBackground MASLD is closely linked to gut–liver axis dysfunction, including altered microbial activity, disturbed bile acid metabolism, and hepatic lipid accumulation. Raspberry polyphenols may help counteract these disturbances, whereas fructooligosaccharides (FOS) may enhance their microbial transformation and biological activity. Methods and results Male Wistar rats were fed for 12 weeks with a control diet, a high-fat low-fiber diet (HF), or HF diets supplemented with raspberry polyphenols alone (HF + PP) or combined with FOS (HF + PP + FOS). Compared with HF feeding alone, the combined treatment produced the most favorable response, including lower hepatic triglyceride and cholesterol accumulation, improved plasma lipid indices, higher hepatic and plasma levels of polyphenol-derived metabolites, reduced hepatic Ahr/AHR expression, increased Cyp8b1/CYP8B1 expression, enhanced short-chain fatty acid production, altered cecal bile acid profile, lower activity of selected bacterial enzymes, and a distinct shift in cecal microbiota composition. Conclusion Combined supplementation with raspberry polyphenols and fructooligosaccharides partly alleviated selected metabolic and intestinal disturbances induced by a high-fat, low-fiber diet. The findings may support the involvement of the gut–liver axis and suggest that FOS may strengthen the functional effects of raspberry polyphenols by promoting microbial fermentation and increasing the formation and availability of smaller bioactive metabolites. Overall, the combination of a polyphenol-rich raspberry preparation with a microbiota-targeting prebiotic may represent a nutritionally relevant strategy for supporting metabolic homeostasis under MASLD-like conditions.eng
dc.identifier.doi10.1016/j.nfs.2026.100286
dc.identifier.eid105045423939
dc.identifier.otherb1c338dd-d5b3-4125-b94a-15d44f92eda2
dc.identifier.urihttp://hdl.handle.net/10400.14/58973
dc.identifier.wos001834910600001
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier GmbH
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBile acid metabolismeng
dc.subjectFunctional foodeng
dc.subjectGut–liver axiseng
dc.subjectNonalcoholic fatty liver diseaseeng
dc.subjectPolyphenol–prebiotic synergyeng
dc.subjectRaspberry polyphenolseng
dc.titleFructooligosaccharides enhance the gut–liver effects of raspberry polyphenols in a rat model of diet-induced metabolic dysfunction-associated steatotic liver disease
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.volume44
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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