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Gastrointestinal delivery of codfish skin-derived collagen hydrolysates: deep eutectic solvent extraction and bioactivity analysis

2024-01-01Journal article Open access
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dc.contributor.authorSilva, Isa
dc.contributor.authorVaz, Bárbara M. C.
dc.contributor.authorSousa, Sérgio
dc.contributor.authorPintado, Maria Manuela
dc.contributor.authorCoscueta, Ezequiel R.
dc.contributor.authorVentura, Sónia P. M.
dc.date.accessioned2023-11-30T12:05:17Z
dc.date.available2023-11-30T12:05:17Z
dc.date.issued2024-01-01
dc.description.abstractThe fishing industry produces substantial by-products, such as heads, skins, bones, and scales, rich in collagen—a prevalent protein in these materials. However, further application of deep eutectic solvent-based extraction remains unexplored. In this study, we extracted collagen with urea: propanoic acid mixture (U:PA; 1:2) with a 2.2% yield, followed by enzymatic hydrolysis with alcalase for 120 min. The resulting bioactive peptides demonstrated notable antioxidant activity (961 µmol TE) and antihypertensive properties (39.3% ACE inhibition). Subsequently, we encapsulated 39.3% of these hydrolysates in chitosan-TPP capsules, which released about 58% of their content, primarily in the intestine, as mimicked in the in vitro model of the gastrointestinal tract. Although the digestion process did not significantly alter the size of the non-encapsulated collagen peptides, it did influence their health benefits. The promising results suggest that further research could optimize the use of collagen from fish by-products, potentially offering a sustainable source for health products.pt_PT
dc.description.versionN/Apt_PT
dc.identifier.doi10.1016/j.foodres.2023.113729pt_PT
dc.identifier.eid85178567050
dc.identifier.issn0963-9969
dc.identifier.urihttp://hdl.handle.net/10400.14/43244
dc.identifier.wos001129931000001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCodfish skinpt_PT
dc.subjectDeep eutectic solventspt_PT
dc.subjectMarine collagenpt_PT
dc.subjectBioactive peptidespt_PT
dc.subjectColon deliverypt_PT
dc.subjectFishery byproductspt_PT
dc.subjectNutraceutical releasept_PT
dc.subjectAtlantic codfishpt_PT
dc.subjectAtlantic codfishpt_PT
dc.titleGastrointestinal delivery of codfish skin-derived collagen hydrolysates: deep eutectic solvent extraction and bioactivity analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFood research internationalpt_PT
oaire.citation.volume175
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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