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Exploring the potential of invasive species Sargassum muticum: microwave-assisted extraction optimization and bioactivity profiling

2024-08Journal article Open access
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dc.contributor.authorSilva, Aurora
dc.contributor.authorCassani, Lucia
dc.contributor.authorCarpena, Maria
dc.contributor.authorLourenço-Lopes, Catarina
dc.contributor.authorGrosso, Clara
dc.contributor.authorChamorro, Franklin
dc.contributor.authorGarcía-Pérez, Pascual
dc.contributor.authorCarvalho, Ana
dc.contributor.authorDomingues, Valentina F.
dc.contributor.authorBarroso, M. Fátima
dc.contributor.authorSimal-Gandara, Jesus
dc.contributor.authorPrieto, Miguel A.
dc.date.accessioned2024-09-09T11:37:33Z
dc.date.available2024-09-09T11:37:33Z
dc.date.issued2024-08
dc.description.abstractSargassum muticum (SM) poses a serious environmental issue since it is a fast-expanding invasive species occupying key areas of the European shoreline, disrupting the autochthonous algae species, and disturbing the ecosystem. This problem has concerned the general population and the scientific community. Nevertheless, as macroalgae are recognized as a source of bioactive molecules, the abundance of SM presents an opportunity as a raw material. In this work, response surface methodology (RSM) was applied as a tool for the optimization of the extraction of bioactive compounds from SM by microwave-assisted extraction (MAE). Five different parameters were used as target functions: yield, total phenolic content (TPC); and the antioxidant measurements of 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), and β-carotene bleaching (BC). After the optimal extraction conditions were determined (time = 14.00 min; pressure = 11.03 bar; ethanol = 33.31%), the chemical composition and bioactivity of the optimum extract was evaluated to appraise its antioxidant capability to scavenge reactive species and as a potential antibacterial, antidiabetic, antiproliferation, and neuroprotective agent. The results lead to the conclusion that MAE crude extract has bioactive properties, being especially active as an antiproliferation agent and as a nitric oxide and superoxide radical scavenger.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/md22080352pt_PT
dc.identifier.eid85202602537
dc.identifier.issn1660-3397
dc.identifier.pmcPMC11355144
dc.identifier.pmid39195468
dc.identifier.urihttp://hdl.handle.net/10400.14/46412
dc.identifier.wos001307139700001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantspt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectMicrowave-assisted extractionpt_PT
dc.subjectSargassum muticumpt_PT
dc.titleExploring the potential of invasive species Sargassum muticum: microwave-assisted extraction optimization and bioactivity profilingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume22pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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