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Exploring chitosan nanoparticles as effective inhibitors of antibiotic resistant skin microorganisms – from in vitro to ex vitro testing

dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorSilva, Sara
dc.contributor.authorVeiga, Mariana
dc.contributor.authorTavaria, Freni K.
dc.contributor.authorPintado, Maria M.
dc.date.accessioned2018-10-16T18:02:15Z
dc.date.available2018-10-16T18:02:15Z
dc.date.issued2018
dc.description.abstractNowadays, nosocomial skin infections are increasingly harder to manage and control. In the search for new, natural compounds capable of being alternatives to traditional antibiotics, chitosan and its nanoparticles, have garnered attention. This work sought to understand the potential of chitosan NPs in the management of infections caused by MDR skin pathogens in planktonic and sessile assays. Additionally, NPs’ capacity to inhibit biofilm quorum sensing and prevent HaCat infections was also evaluated. The results obtained showed that chitosan NPs had an average size and charge of 226.6 ± 5.24 nm and +27.1 ± 3.09 mV. Inhibitory and bactericidal concentrations varied between 1 and 2 mg/mL and 2–7 mg/mL, respectively. Chitosan NPs effectively inhibited biofilm growth for all microorganisms and possessed strong anti-quorum sensing activity. Lastly, chitosan NPs proved to be effective interfere with A. baumannii’s infection of HaCat cells, as they significantly reduced intracellular and extracellular bacterial counts.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCosta, E.M., Silva, S., Veiga, M., Tavaria, F.K., Pintado, M.E. (2018). Exploring chitosan nanoparticles as effective inhibitors of antibiotic resistant skin microorganisms – From in vitro to ex vitro testing. Carbohydrate Polymers, 201, 340-346pt_PT
dc.identifier.doi10.1016/j.carbpol.2018.08.083pt_PT
dc.identifier.eid85052243985
dc.identifier.eissn1879-1344
dc.identifier.issn0144-8617
dc.identifier.pmid30241827
dc.identifier.urihttp://hdl.handle.net/10400.14/25786
dc.identifier.wos000445030100036
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationTextile staining: Toward a greener and functional solution
dc.subjectChitosan nanoparticlespt_PT
dc.subjectMDRpt_PT
dc.subjectAntimicrobialpt_PT
dc.subjectAntibiofilmpt_PT
dc.subjectHaCat infectionpt_PT
dc.titleExploring chitosan nanoparticles as effective inhibitors of antibiotic resistant skin microorganisms – from in vitro to ex vitro testingpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTextile staining: Toward a greener and functional solution
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F103957%2F2014/PT
oaire.citation.endPage346
oaire.citation.startPage340
oaire.citation.titleCarbohydrate Polymerspt_PT
oaire.citation.volume201pt_PT
oaire.fundingStream5876
person.familyNameCosta
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameFreni
person.givenNameMaria Manuela
person.identifier456608
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicatione42f563a-5b1e-4586-b302-efabe7ce07da
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication.latestForDiscovery4f32e563-443f-4eff-8fea-e0916c20afa1
relation.isProjectOfPublication3fe5970e-de39-42f7-a29d-18521b591a09
relation.isProjectOfPublication55e08ab7-bec9-4c02-b25c-4a8139736b4f
relation.isProjectOfPublication.latestForDiscovery55e08ab7-bec9-4c02-b25c-4a8139736b4f

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