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Anti-proliferative, anti-inflammatory, anti-ulcerogenic and wound healing properties of chitosan

2016Journal article Restricted access
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dc.contributor.authorTavaria, Freni
dc.contributor.authorJorge, Michelle P.
dc.contributor.authorLúcia T.G. Ruiz, Ana
dc.contributor.authorPintado, M. E.
dc.contributor.authorCarvalho, João E.
dc.date.accessioned2017-10-17T09:08:20Z
dc.date.available2017-10-17T09:08:20Z
dc.date.issued2016
dc.description.abstractIn this study, anti-inflammatory, wound healing and anti-ulcerogenic properties of chitosan were evaluated ‘in vivo’ using wistar rats and swiss adult mice and the anti-proliferative activity was tested ‘in vitro’. The tested chitosans displayed no anti-proliferative or anti-inflammatory properties. The cytotoxic activity of chitosan was found to be non-existent towards eight tumoral cell lines and no significant differences were found in the ear edema (anti-inflammatory model) induced by croton oil and chitosan groups. However, chitosan showed good anti-ulcerative and wound healing abilities. Low molecular weight (LMW) chitosan effectively reduced ulcerative wounds induced by ethanol, while high molecular weight (HMW) chitosan helped retain the stomachal folds rendering a gastro protective effect. These results suggest that chitosan can potentially be used in the treatment of peptic ulcers. HMW chitosan also potentiated the healing process both in normal and diabetic rats, probably without induction of fibroblast growth but via collagen synthesispt_PT
dc.description.versionN/Apt_PT
dc.identifier.citationTAVARIA, Freni; JORGE, Michelle P.; RUIZ, Ana Lúcia T.G.; PINTADO, M. E.; CARVALHO, João E. - Anti-Proliferative, Anti-Inflammatory, Anti-Ulcerogenic and Wound Healing Properties of Chitosan. Current Bioactive Compounds. ISSN 1875-6646. Vol. 12, n.º 2 (2016) p. 114-122pt_PT
dc.identifier.doi10.2174/1573407212666160330204522pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.14/23132
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier
dc.subjectChitosanpt_PT
dc.subjectWound healingpt_PT
dc.subjectAnti-ulcerativept_PT
dc.subjectAnti-proliferativept_PT
dc.subjectBiological propertiespt_PT
dc.subjectIn vivo testingpt_PT
dc.titleAnti-proliferative, anti-inflammatory, anti-ulcerogenic and wound healing properties of chitosanpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F24222%2F2005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.citation.titleCurrent Bioactive Compoundspt_PT
oaire.citation.volume25
oaire.fundingStreamSFRH
oaire.fundingStream5876
person.familyNameKekhasharú Tavaria
person.familyNameJorge
person.familyNameTasca Gois Ruiz
person.familyNamePintado
person.givenNameFreni
person.givenNameMarianna
person.givenNameAna Lúcia
person.givenNameMaria Manuela
person.identifier456608
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-8459-6707
person.identifier.orcid0000-0002-0844-8702
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id55352400600
person.identifier.scopus-author-id7203007412
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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