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Omega-3- and resveratrol-loaded lipid nanosystems for potential use as topical formulations in autoimmune, inflammatory, and cancerous skin diseases

2021-08Journal article Open access
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dc.contributor.authorCaldas, Ana R.
dc.contributor.authorCatita, José
dc.contributor.authorMachado, Raul
dc.contributor.authorRibeiro, Artur
dc.contributor.authorCerqueira, Fátima
dc.contributor.authorHorta, Bruno
dc.contributor.authorMedeiros, Rui
dc.contributor.authorLúcio, Marlene
dc.contributor.authorLopes, Carla M.
dc.date.accessioned2021-09-06T14:34:48Z
dc.date.available2021-09-06T14:34:48Z
dc.date.issued2021-08
dc.description.abstractResveratrol (RSV) and omega 3 (!3), because of their biological favorable properties, have become subjects of interest for researchers in dermocosmetic and pharmaceutical industries; however, these bioactives present technological limitations that hinder their effective delivery to the target skin layer. To overcome the stability and skin permeation limitations of free bioactives, this work proposes a combined strategy involving two different lipid nanosystems (liposomes and lipid nanoparticles) that include ω3 in their lipid matrix. Additionaly, RSV is only encapsulated in liposomes that provid an adequate amphiphilic environment. Each formulation is thoroughly characterized regarding their physical–chemical properties. Subsequently, the therapeutic performance of the lipid nanosystems is evaluated based on their protective roles against lipid peroxidation, as well as inhibition of cicloxygenase (COX) and nitric oxid (NO) production in the RWA264.7 cell line. Finally, the lipid nanosystems are incorporated in hydrogel to allow their topical administration, then rheology, occlusion, and RSV release–diffusion assays are performed. Lipid nanoparticles provide occlusive effects at the skin surface. Liposomes provide sustained RSV release and their flexibility conferred by edge activator components enhances RSV diffusion, which is required to reach NO production cells and COX cell membrane enzymes. Overall, the inclusion of both lipid nanosystems in the same semisolid base constitutes a promising strategy for autoimmune, inflammatory, and cancerous skin diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/pharmaceutics13081202pt_PT
dc.identifier.eid85112325242
dc.identifier.issn1999-4923
dc.identifier.pmcPMC8401194
dc.identifier.pmid34452163
dc.identifier.urihttp://hdl.handle.net/10400.14/34657
dc.identifier.wos000690195000001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantpt_PT
dc.subjectCOX inhibitorspt_PT
dc.subjectLipid nanosystemspt_PT
dc.subjectNO inhibitory effectpt_PT
dc.subjectOmega 3pt_PT
dc.subjectResveratrolpt_PT
dc.subjectTopical skin administrationpt_PT
dc.titleOmega-3- and resveratrol-loaded lipid nanosystems for potential use as topical formulations in autoimmune, inflammatory, and cancerous skin diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume13pt_PT
person.familyNameCatita
person.familyNameMachado
person.familyNameRibeiro
person.familyNameCerqueira
person.familyNameGuedes Horta
person.familyNameMedeiros
person.familyNameLúcio
person.familyNameLopes
person.givenNameJose
person.givenNameRaul
person.givenNameArtur
person.givenNameFátima
person.givenNameBruno Miguel
person.givenNameRui
person.givenNameMarlene
person.givenNameCarla
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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