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Carbamazepine is degraded by the bacterial strain Labrys portucalensis F11

2019Journal article Restricted access
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dc.contributor.authorBessa, Vânia S.
dc.contributor.authorMoreira, Irina S.
dc.contributor.authorMurgolo, Sapia
dc.contributor.authorMascolo, Giuseppe
dc.contributor.authorCastro, Paula M. L.
dc.date.accessioned2019-07-11T17:19:14Z
dc.date.available2019-07-11T17:19:14Z
dc.date.issued2019
dc.description.abstractThe occurrence of pharmaceuticals in the environment is a topic of concern. Carbamazepine (CBZ) is a widespread antiepileptic drug and due to its physical-chemical characteristics minimal removal is achieved in conventional water treatments, and thus has been suggested as a molecular marker of wastewater contamination in surface water and groundwater. The present study reports the biotransformation of CBZ by the bacterial strain Labrys portucalensis F11. When supplied as a sole carbon source, a 95.4% biotransformation of 42.69 μM CBZ was achieved in 30 days. In co-metabolism with acetate, complete biotransformation was attained at a faster rate. Following a target approach, the detection and identification of 14 intermediary metabolites was achieved through UPLC-QTOF/MS/MS. Biotransformation of CBZ by the bacterial strain is mostly based on oxidation, loss of -CHNO group and ketone formation reactions; a biotransformation pathway with two routes is proposed. The toxicity of untreated and treated CBZ solutions was assessed using Vibrio Fischeri and Lepidium sativum acute toxicity tests and Toxi-Chromo Test. The presence of CBZ and/or its degradations products in solution resulted in moderate toxic effect on Vibrio Fischeri, whereas the other organisms were not affected. To the best of our knowledge this is the first report that proposes the metabolic degradation pathway of CBZ by a single bacterial strain.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBessa, V. S., Moreira, I. S., Murgolo, S., Mascolo, G., & Castro, P. M. L. (2019). Carbamazepine is degraded by the bacterial strain Labrys portucalensis F11. Science of The Total Environment, 690, 739–747. https://doi.org/10.1016/j.scitotenv.2019.06.461pt_PT
dc.identifier.doi10.1016/j.scitotenv.2019.06.461pt_PT
dc.identifier.eid85068582180
dc.identifier.eissn1879-1026
dc.identifier.issn0048-9697
dc.identifier.pmid31301512
dc.identifier.urihttp://hdl.handle.net/10400.14/27929
dc.identifier.wos000482549900069
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-031264
dc.relationAGeNT - Aerobic Granular Sludge technology combined with selected microbial agents to degrade toxic pollutants from wastewater
dc.relationCentre for Biotechnology and Fine Chemistry
dc.subjectCarbamazepinept_PT
dc.subjectLabrys portucalensis F11pt_PT
dc.subjectBiotransformationpt_PT
dc.subjectMetabolitespt_PT
dc.subjectCo-metabolismpt_PT
dc.subjectToxicitypt_PT
dc.titleCarbamazepine is degraded by the bacterial strain Labrys portucalensis F11pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAGeNT - Aerobic Granular Sludge technology combined with selected microbial agents to degrade toxic pollutants from wastewater
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F90146%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBTA-BTA%2F31264%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.citation.endPage747
oaire.citation.startPage739
oaire.citation.titleScience of the Total Environmentpt_PT
oaire.citation.volume690pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream9471 - RIDTI
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBessa
person.familyNameMoreira
person.familyNameMascolo
person.familyNameCastro
person.givenNameVânia
person.givenNameIrina Susana Sousa
person.givenNameGiuseppe
person.givenNamePaula
person.identifierK-5841-2014
person.identifier2013444
person.identifier.ciencia-id161E-A350-7FDE
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.orcid0000-0002-2676-7184
person.identifier.orcid0000-0001-6516-0994
person.identifier.orcid0000-0002-7858-2114
person.identifier.orcid0000-0001-8841-6606
person.identifier.ridK-8029-2014
person.identifier.ridK-5841-2014
person.identifier.ridK-3240-2012
person.identifier.ridM-8241-2013
person.identifier.scopus-author-id35214245200
person.identifier.scopus-author-id36798094100
person.identifier.scopus-author-id7102781782
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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