Publication
Ultrasound-assisted extraction of bioactive compounds from goji berries: optimization, bioactivity, and intestinal permeability assessment
| dc.contributor.author | Teixeira, Filipa | |
| dc.contributor.author | Silva, Ana Margarida | |
| dc.contributor.author | Sut, Stefania | |
| dc.contributor.author | Dall'Acqua, Stefano | |
| dc.contributor.author | Ramos, Oscar L. | |
| dc.contributor.author | Ribeiro, Alessandra B. | |
| dc.contributor.author | Ferraz, Ricardo | |
| dc.contributor.author | Delerue-Matos, Cristina | |
| dc.contributor.author | Rodrigues, Francisca | |
| dc.date.accessioned | 2024-05-22T17:12:09Z | |
| dc.date.available | 2024-05-22T17:12:09Z | |
| dc.date.issued | 2024-07 | |
| dc.description.abstract | Lycium barbarum L. berries have a remarkable chemical composition and extensive biological activities, being a valuable component of health and nutraceutical practices. Nevertheless, a deep insight on the intestinal permeation of the pro-healthy bioactive compounds is urgently needed to predict the real effects on human body. This study attempted, for the first time, to optimize the Ultrasound-Assisted Extraction (UAE) of goji berries using a Response Surface Methodology approach and establish the intestinal permeation of the principal pro-healthy compounds. The optimal extraction conditions were a solid:liquid ratio of 8.75 % for 56.21 min, using an intensity of 59.05 W/m2. The optimal extract displayed a remarkable antioxidant capacity, with LC/DAD-ESI-MS analysis unveiled a diverse phytochemical profile, encompassing different compounds (e.g. glu-lycibarbarspermidine F, 2-glu-kukoamine, rutin, 3,5-dicaffeoylquinic acid). The intestinal co-culture model demonstrated that glu-lycibarbarspermidine F (isomer 2) (73.70 %), 3,5-dicaffeoylquinic acid (52.66 %), and isorhamnetin-3-O-rutinoside (49.31 %) traversed the intestinal cell layer, exerting beneficial health-promoting effects. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1016/j.foodres.2024.114502 | pt_PT |
| dc.identifier.eid | 85192831097 | |
| dc.identifier.issn | 0963-9969 | |
| dc.identifier.pmid | 38823845 | |
| dc.identifier.uri | http://hdl.handle.net/10400.14/45238 | |
| dc.identifier.wos | 001241464900001 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Intestinal permeation | pt_PT |
| dc.subject | Lycium barbarum | pt_PT |
| dc.subject | Phenolic compounds | pt_PT |
| dc.subject | Response surface methodology | pt_PT |
| dc.subject | Ultrasound-assisted extraction | pt_PT |
| dc.title | Ultrasound-assisted extraction of bioactive compounds from goji berries: optimization, bioactivity, and intestinal permeability assessment | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.title | Food Research International | pt_PT |
| oaire.citation.volume | 188 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |