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Microbial production of conjugated linoleic acid and conjugated linolenic acid relies on a multienzymatic system

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dc.contributor.authorSalsinha, Ana S.
dc.contributor.authorPimentel, Lígia L.
dc.contributor.authorFontes, Ana L.
dc.contributor.authorGomes, Ana M.
dc.contributor.authorRodríguez-Alcalá, Luis M.
dc.date.accessioned2019-10-23T10:43:18Z
dc.date.available2019-10-23T10:43:18Z
dc.date.issued2018
dc.description.abstractConjugated linoleic acids (CLAs) and conjugated linolenic acids (CLNAs) have gained significant attention due to their anticarcinogenic and lipid/energy metabolism-modulatory effects. However, their concentration in foodstuffs is insufficient for any therapeutic application to be implemented. From a biotechnological standpoint, microbial production of these conjugated fatty acids (CFAs) has been explored as an alternative, and strains of the genera Propionibacterium, Lactobacillus, and Bifidobacterium have shown promising producing capacities. Current screening research works are generally based on direct analytical determination of production capacity (e.g., trial and error), representing an important bottleneck in these studies. This review aims to summarize the available information regarding identified genes and proteins involved in CLA/CLNA production by these groups of bacteria and, consequently, the possible enzymatic reactions behind such metabolic processes. Linoleate isomerase (LAI) was the first enzyme to be described to be involved in the microbiological transformation of linoleic acids (LAs) and linolenic acids (LNAs) into CFA isomers. Thus, the availability of lai gene sequences has allowed the development of genetic screening tools. Nevertheless, several studies have reported that LAIs have significant homology with myosin-cross-reactive antigen (MCRA) proteins, which are involved in the synthesis of hydroxy fatty acids, as shown by hydratase activity. Furthermore, it has been suggested that CLA and/or CLNA production results from a stress response performed by the activation of more than one gene in a multiple-step reaction. Studies on CFA biochemical pathways are essential to understand and characterize the metabolic mechanism behind this process, unraveling all the gene products that may be involved. As some of these bacteria have shown modulation of lipid metabolism in vivo, further research to be focused on this topic may help us to understand the role of the gut microbiota in human health.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSalsinha, A.S., Pimentel, L.L., Fontes, A.L., Gomes, A.M., Rodríguez-Alcalá, L.M. (2018). Microbial Production of Conjugated Linoleic Acid and Conjugated Linolenic Acid Relies on a Multienzymatic System. Microbiology and Molecular Biology Reviews, 82(4), art. n.º e00019-18pt_PT
dc.identifier.doi10.1128/MMBR.00019-18pt_PT
dc.identifier.eid85054144471
dc.identifier.eissn1098-5557
dc.identifier.issn1092-2172
dc.identifier.pmcPMC6298612
dc.identifier.pmid30158254
dc.identifier.urihttp://hdl.handle.net/10400.14/28494
dc.identifier.wos000450037700002
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Microbiologypt_PT
dc.relationImpact of microbial produced bioactive CLA and CLnA on acquired and genetic obesity and on gut microbiota in a murine model
dc.relationDevelopment of a new functional dairy product enriched in microbial bioactive conjugated fatty acids through an industrial-based approach
dc.titleMicrobial production of conjugated linoleic acid and conjugated linolenic acid relies on a multienzymatic systempt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleImpact of microbial produced bioactive CLA and CLnA on acquired and genetic obesity and on gut microbiota in a murine model
oaire.awardTitleDevelopment of a new functional dairy product enriched in microbial bioactive conjugated fatty acids through an industrial-based approach
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-TEC%2F2125%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F119785%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F117721%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.citation.issue4
oaire.citation.titleMicrobiology and Molecular Biology Reviewspt_PT
oaire.citation.volume82
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
person.familyNameSalsinha
person.familyNamePimentel
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person.familyNameGomes
person.familyNameRodríguez-Alcalá
person.givenNameAna Sofia
person.givenNameLígia
person.givenNameAna Luiza
person.givenNameAna Maria
person.givenNameLuis Miguel
person.identifier534450
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person.identifier.ciencia-id6E14-F8F8-755E
person.identifier.orcid0000-0003-1679-299X
person.identifier.orcid0000-0002-6656-017X
person.identifier.orcid0000-0002-5664-2200
person.identifier.orcid0000-0001-7883-2446
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person.identifier.ridK-3254-2014
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person.identifier.ridJ-3239-2012
person.identifier.scopus-author-id57204031465
person.identifier.scopus-author-id22035944100
person.identifier.scopus-author-id57000067200
person.identifier.scopus-author-id57190668768
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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