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Blueberry counteracts prediabetes in a hypercaloric diet-induced rat model and rescues hepatic mitochondrial bioenergetics

2021-11-23Journal article Open access
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dc.contributor.authorNunes, Sara
dc.contributor.authorViana, Sofia D.
dc.contributor.authorPreguiça, Inês
dc.contributor.authorAlves, André
dc.contributor.authorFernandes, Rosa
dc.contributor.authorTeodoro, João S.
dc.contributor.authorMatos, Patrícia
dc.contributor.authorFigueirinha, Artur
dc.contributor.authorSalgueiro, Lígia
dc.contributor.authorAndré, Alexandra
dc.contributor.authorSilva, Sara
dc.contributor.authorJarak, Ivana
dc.contributor.authorCarvalho, Rui A.
dc.contributor.authorCavadas, Cláudia
dc.contributor.authorRolo, Anabela P.
dc.contributor.authorPalmeira, Carlos M.
dc.contributor.authorPintado, Maria M.
dc.contributor.authorReis, Flávio
dc.date.accessioned2021-12-03T18:25:18Z
dc.date.available2021-12-03T18:25:18Z
dc.date.issued2021-11-23
dc.description.abstractThe paramount importance of a healthy diet in the prevention of type 2 diabetes is now well recognized. Blueberries (BBs) have been described as attractive functional fruits for this purpose. This study aimed to elucidate the cellular and molecular mechanisms pertaining to the protective impact of blueberry juice (BJ) on prediabetes. Using a hypercaloric diet-induced prediabetic rat model, we evaluated the effects of BJ on glucose, insulin, and lipid profiles; gut microbiota composition; intestinal barrier integrity; and metabolic endotoxemia, as well as on hepatic metabolic surrogates, including several related to mitochondria bioenergetics. BJ supplementation for 14 weeks counteracted diet-evoked metabolic deregulation, improving glucose tolerance, insulin sensitivity, and hypertriglyceridemia, along with systemic and hepatic antioxidant properties, without a significant impact on the gut microbiota composition and related mechanisms. In addition, BJ treatment effectively alleviated hepatic steatosis and mitochondrial dysfunction observed in the prediabetic animals, as suggested by the amelioration of bioenergetics parameters and key targets of inflammation, insulin signaling, ketogenesis, and fatty acids oxidation. In conclusion, the beneficial metabolic impact of BJ in prediabetes may be mainly explained by the rescue of hepatic mitochondrial bioenergetics. These findings pave the way to support the use of BJ in prediabetes to prevent diabetes and its complications.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/nu13124192pt_PT
dc.identifier.eid85119606449
dc.identifier.issn2072-6643
dc.identifier.pmcPMC8706913
dc.identifier.pmid34959746
dc.identifier.urihttp://hdl.handle.net/10400.14/36102
dc.identifier.wos000736901900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBlueberriespt_PT
dc.subjectGut microbiotapt_PT
dc.subjectHepatic energy metabolismpt_PT
dc.subjectHepatoprotectionpt_PT
dc.subjectHypercaloric diet-induced prediabetespt_PT
dc.subjectMitochondria functionpt_PT
dc.titleBlueberry counteracts prediabetes in a hypercaloric diet-induced rat model and rescues hepatic mitochondrial bioenergeticspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume13pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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