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Silk fibroin–alginate aerogel beads produced by supercritical CO2 drying: a dual-function conformable and haemostatic dressing

2025-08-02Research article Open access
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dc.contributor.authorSellitto, Maria Rosaria
dc.contributor.authorLarobina, Domenico
dc.contributor.authorSoricellis, Chiara De
dc.contributor.authorAmante, Chiara
dc.contributor.authorFalcone, Giovanni
dc.contributor.authorRusso, Paola
dc.contributor.authorBernardes, Beatriz G.
dc.contributor.authorOliveira, Ana Leite
dc.contributor.authorGaudio, Pasquale Del
dc.date.accessioned2025-08-13T08:43:53Z
dc.date.available2025-08-13T08:43:53Z
dc.date.issued2025-08-02
dc.description.abstractInfection control and bleeding management in deep wounds remain urgent and unmet clinical challenges that demand innovative, multifunctional, and sustainable solutions. Unlike previously reported sodium alginate and silk fibroin-based gel formulations, the present work introduces a dual-functional system combining antimicrobial and haemostatic activity in the form of conformable aerogel beads. This dual-functional formulation is designed to absorb exudate, promote clotting, and provide localized antimicrobial action, all essential for accelerating wound repair in high-risk scenarios within a single biocompatible system. Aerogel beads were obtained by supercritical drying of a silk fibroin–sodium alginate blend, resulting in highly porous, spherical structures measuring 3–4 mm in diameter. The formulations demonstrated efficient ciprofloxacin encapsulation (42.75–49.05%) and sustained drug release for up to 12 h. Fluid absorption reached up to four times their weight in simulated wound fluid and was accompanied by significantly enhanced blood clotting, outperforming a commercial haemostatic dressing. These findings highlight the potential of silk-based aerogel beads as a multifunctional wound healing platform that combines localized antimicrobial delivery, efficient fluid and exudate management, biodegradability, and superior haemostatic performance in a single formulation. This work also shows for the first time how the prilling encapsulation technique with supercritical drying is able to successfully produce silk fibroin and sodium alginate composite aerogel beads.eng
dc.identifier.doi10.3390/gels11080603
dc.identifier.eid105014330688
dc.identifier.issn2310-2861
dc.identifier.otherdf9303b9-ad6d-482f-abf7-3ab0d5dcbb04
dc.identifier.urihttp://hdl.handle.net/10400.14/54490
dc.identifier.wos001559665000001
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAerogel beads
dc.subjectAntibiotic delivery
dc.subjectPrilling technique
dc.subjectSilk fibroin
dc.subjectSupercritical CO2 drying
dc.subjectWound healing
dc.titleSilk fibroin–alginate aerogel beads produced by supercritical CO2 drying: a dual-function conformable and haemostatic dressingeng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.titleGels
oaire.citation.volume11
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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