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Anti-biofilm potential of phenolic acids: the influence of environmental pH and intrinsic physico-chemical properties

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dc.contributor.authorSilva, Sara
dc.contributor.authorCosta, Eduardo M.
dc.contributor.authorHorta, Bruno
dc.contributor.authorCalhau, Conceição
dc.contributor.authorMorais, R. M. S. C.
dc.contributor.authorPintado, M. E.
dc.date.accessioned2017-10-12T16:57:45Z
dc.date.available2017-10-12T16:57:45Z
dc.date.issued2016
dc.description.abstractPhenolic acids are a particular group of small phenolic compounds which have exhibited some anti-biofilm activity, although the link between their activity and their intrinsic pH is not clear. Therefore, the present work examined the anti-biofilm activity (inhibition of biomass and metabolic activity) of phenolic acids in relation to the environmental pH, as well as other physico-chemical properties. The results indicate that, while Escherichia coli was not inhibited by the phenolic acids, both methicillin resistant Staphylococcus aureus and methicillin resistant Staphylococcus epidermidis were susceptible to the action of all phenolic acids, with the pH playing a relevant role in the activity: a neutral pH favored MRSE inhibition, while acidic conditions favored MRSA inhibition. Some links between molecular polarity and size were associated only with their potential as metabolic inhibitors, with the overall interactions hinting at a membrane-based mechanism for MRSA and a cytoplasmic effect for MRSE.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSILVA, Sara; COSTA, Eduardo M.; HORTA, Bruno; CALHAU, Conceição; MORAIS, R. M. S. C.; PINTADO, M. E. - Anti-biofilm potential of phenolic acids: The influence of environmental pH and intrinsic physico-chemical properties. Biofouling. ISSN 1029-2454. Vol. 32, n.º 8 (2016), p. 853-860pt_PT
dc.identifier.doi10.1080/08927014.2016.1208183pt_PT
dc.identifier.eid84983242619
dc.identifier.pmid27434592
dc.identifier.urihttp://hdl.handle.net/10400.14/23058
dc.identifier.wos000381042800002
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationTextile staining: Toward a greener and functional solution
dc.subjectPhenolic acidspt_PT
dc.subjectAnti-biofilm activitypt_PT
dc.subjectMRSEpt_PT
dc.subjectMRSApt_PT
dc.subjectEscherichia colipt_PT
dc.titleAnti-biofilm potential of phenolic acids: the influence of environmental pH and intrinsic physico-chemical propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTextile staining: Toward a greener and functional solution
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F50016%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F90867%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBDE%2F103957%2F2014/PT
oaire.citation.issue8
oaire.citation.titleBiofoulingpt_PT
oaire.citation.volume32
oaire.fundingStream5876
oaire.fundingStreamSFRH
person.familyNameSilva
person.familyNameCosta
person.familyNameCalhau
person.familyNameMorais
person.familyNamePintado
person.givenNameSara
person.givenNameEduardo
person.givenNameConceição
person.givenNameRui M. S. C.
person.givenNameMaria Manuela
person.identifier1888852
person.identifier143926
person.identifier456608
person.identifier.ciencia-id8E18-0AFF-BF6D
person.identifier.ciencia-idB218-870B-98B5
person.identifier.ciencia-id2110-0420-1717
person.identifier.ciencia-id541B-04AE-0686
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0001-8268-2137
person.identifier.orcid0000-0003-3121-4514
person.identifier.orcid0000-0001-9567-3379
person.identifier.orcid0000-0001-5138-6941
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-5065-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55158300800
person.identifier.scopus-author-id55249865700
person.identifier.scopus-author-id6701578877
person.identifier.scopus-author-id7005146997
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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