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Phenylethyl isothiocyanate: a bioactive agent for gastrointestinal health

2022-02-01Journal article Open access
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dc.contributor.authorCoscueta, Ezequiel R.
dc.contributor.authorSousa, Ana Sofia
dc.contributor.authorReis, Celso A.
dc.contributor.authorPintado, Maria Manuela
dc.date.accessioned2022-02-10T11:07:29Z
dc.date.available2022-02-10T11:07:29Z
dc.date.issued2022-02-01
dc.description.abstractThe incidence of gastrointestinal pathologies (cancer in particular) has increased progressively, with considerable morbidity and mortality, and a high economic impact on the healthcare system. The dietary intake of natural phytochemicals with certain bioactive properties has shown therapeutic and preventive effects on these pathologies. This includes the cruciferous vegetable derivative phenylethyl isothiocyanate (PEITC), a bioactive compound present in some vegetables, such as watercress. Notably, PEITC has antioxidant, anti-inflammatory, bactericidal, and anticarcinogenic properties. This review summarized the current knowledge on the role of PEITC as a potential natural nutraceutical or an adjuvant against oxidative/inflammatory-related disorders in the gastrointestinal tract. We also discussed the safe and recommended dose of PEITC. In addition, we established a framework to guide the research and development of sustainable methodologies for obtaining and stabilizing this natural molecule for industrial use. With PEITC, there is great potential to develop a viable strategy for preventing cancer and other associated diseases of the gastrointestinal tract. However, this topic still needs more scientific studies to help develop new PEITC products for the nutraceutical, pharmaceutical, or food industries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules27030794pt_PT
dc.identifier.eid85123613067
dc.identifier.issn1420-3049
dc.identifier.pmcPMC8838155
dc.identifier.pmid35164058
dc.identifier.urihttp://hdl.handle.net/10400.14/36643
dc.identifier.wos35164058
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectGastrointestinal healthpt_PT
dc.subjectNatural anti-cancerpt_PT
dc.subjectNatural anti-inflammatorypt_PT
dc.subjectNatural antioxidantpt_PT
dc.subjectNutraceuticalpt_PT
dc.subjectWatercresspt_PT
dc.titlePhenylethyl isothiocyanate: a bioactive agent for gastrointestinal healthpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume27pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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