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Effect of cerium-containing hydroxyapatite in bone repair in female rats with osteoporosis induced by ovariectomy

2021-04Journal article Open access
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dc.contributor.authorVieira, Ewerton
dc.contributor.authorSilva, Marcos
dc.contributor.authorMaia-Filho, Antonio
dc.contributor.authorFerreira, Daniel
dc.contributor.authorFiguerêdo-Silva, José
dc.contributor.authorRovaris, Karla
dc.contributor.authorFialho, Ana Cristina
dc.contributor.authorLeite-Oliveira, Ana
dc.contributor.authorOliveira, André L. Menezes de
dc.contributor.authorFonseca, Maria Gardênnia da
dc.contributor.authorOsajima, Josy A.
dc.contributor.authorSilva-Filho, Edon C. da
dc.date.accessioned2021-04-14T14:11:58Z
dc.date.available2021-04-14T14:11:58Z
dc.date.issued2021-04
dc.description.abstractOsteoporosis is a public health problem, with bone loss being the main consequence. Hydroxyapatite (HA) has been largely used as a bioceramic to stimulate bone growth. In our work, a cerium-containing HA (Ce-HA) has been proposed and its effects on the antimicrobial and bone-inducing properties were investigated. The synthesis of the materials occurred by the suspension–precipitation method (SPM). The XRD (X-ray Diffraction) confirmed the crystalline phase, and the Rietveld refinement confirmed the crystallization of HA and Ce-HA in a hexagonal crystal structure in agreement with ICSD n◦ 26205. Characterizations by FT-IR (Fourier Transform Infrared Spectroscopy), XPS (X-ray Photoemission Spectroscopy), and FESEM-EDS (Field Emission Scanning Electron Microscope-Energy Dispersive X-ray Spectroscopy) confirmed the presence of cerium (Ce3+ and Ce4+ ). The antibacterial activity of Has was evaluated against Staphylococcus aureus 25,923 and Escherichia coli 25,922 strains, which revealed that the material has antimicrobial properties and the cytotoxicity assay indicated that Ce-containing HA was classified as non-toxic. The effects of Ce-HA on bone repair, after application in bone defects in the tibia of female rats with osteoporosis induced by ovariectomy (OVX), were evaluated. After 15 and 30 days of implantation, the samples were analyzed by Raman, histology and X-ray microtomography. The results showed that the animals that had the induced bone defects filled with the Ce-HA materials had more expressive bone neoformation than the control group.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/min11040377pt_PT
dc.identifier.eid85103490645
dc.identifier.issn2075-163X
dc.identifier.urihttp://hdl.handle.net/10400.14/32580
dc.identifier.wos000643331900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBone regenerationpt_PT
dc.subjectCeriumpt_PT
dc.subjectHydroxyapatitept_PT
dc.subjectOsteoporosispt_PT
dc.subjectOvariectomypt_PT
dc.titleEffect of cerium-containing hydroxyapatite in bone repair in female rats with osteoporosis induced by ovariectomypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.titleMineralspt_PT
oaire.citation.volume11pt_PT
person.familyNameVieira
person.familyNameFigueredo-Silva
person.familyNameFialho
person.familyNameOliveira
person.familyNameMenezes
person.familyNameFonseca
person.familyNameOsajima
person.familyNameSilva Filho
person.givenNameEwerton Gomes
person.givenNameJosé
person.givenNameAna Cristina
person.givenNameAna
person.givenNameAndré
person.givenNameMaria
person.givenNameJosy
person.givenNameEdson
person.identifier1415634
person.identifier760930
person.identifier.ciencia-id4713-31C8-A356
person.identifier.orcid0000-0002-9537-2995
person.identifier.orcid0000-0002-7117-8784
person.identifier.orcid0000-0002-2973-1080
person.identifier.orcid0000-0001-8012-4203
person.identifier.orcid0000-0002-7930-6234
person.identifier.orcid0000-0002-7818-4917
person.identifier.orcid0000-0001-7089-3244
person.identifier.orcid0000-0003-0988-2970
person.identifier.ridJ-3404-2013
person.identifier.ridJ-3015-2013
person.identifier.ridD-6401-2013
person.identifier.scopus-author-id57191865503
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id57193491385
person.identifier.scopus-author-id26641091600
person.identifier.scopus-author-id16507501000
person.identifier.scopus-author-id6508173867
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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