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Smart-data-driven system for alzheimer disease detection through electroencephalographic signals

dc.contributor.authorAraújo, Teresa
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorRodrigues, Pedro Miguel
dc.date.accessioned2022-04-01T16:23:39Z
dc.date.available2022-04-01T16:23:39Z
dc.date.issued2022-03
dc.description.abstractBackground: Alzheimer’s Disease (AD) stands out as one of the main causes of dementia worldwide and it represents around 65% of all dementia cases, affecting mainly elderly people. AD is composed of three evolutionary stages: Mild Cognitive Impairment (MCI), Mild and Moderate AD (ADM) and Advanced AD (ADA). It is crucial to create a tool for assisting AD diagnosis in its early stages with the aim of halting the disease progression. Methods: The main purpose of this study is to develop a system with the ability of differentiate each disease stage by means of Electroencephalographic Signals (EEG). Thereby, an EEG nonlinear multi-band analysis by Wavelet Packet was performed enabling to extract several features from each study group. Classic Machine Learning (ML) and Deep Learning (DL) methods have been used for data classification per EEG channel. Results: The maximum accuracies obtained were 78.9% (Healthy controls (C) vs. MCI), 81.0% (C vs. ADM), 84.2% (C vs. ADA), 88.9% (MCI vs. ADM), 93.8% (MCI vs. ADA), 77.8% (ADM vs. ADA) and 56.8% (All vs. All). Conclusions: The proposed method outperforms previous studies with the same database by 2% in binary comparison MCI vs. ADM and central and parietal brain regions revealed abnormal activity as AD progresses.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/bioengineering9040141pt_PT
dc.identifier.eid85128061173
dc.identifier.issn2306-5354
dc.identifier.pmcPMC9031324
dc.identifier.pmid35447701
dc.identifier.urihttp://hdl.handle.net/10400.14/37235
dc.identifier.wos000785327700001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAlzheimer diseasept_PT
dc.subjectNonlinear multi-band analysispt_PT
dc.subjectElectroencephalographicpt_PT
dc.subjectClassic machine learningpt_PT
dc.subjectDeep learningpt_PT
dc.subjectWavelet packetpt_PT
dc.subjectClassificationpt_PT
dc.titleSmart-data-driven system for alzheimer disease detection through electroencephalographic signalspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBioengineeringpt_PT
oaire.citation.volume9pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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