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New prospects in skin regeneration and repair using nanophased hydroxyapatite embedded in collagen nanofibers

2021-04Journal article Open access
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dc.contributor.authorRibeiro, Nilza
dc.contributor.authorSousa, Aureliana
dc.contributor.authorCunha-Reis, Cassilda
dc.contributor.authorOliveira, Ana Leite
dc.contributor.authorGranja, Pedro L.
dc.contributor.authorMonteiro, Fernando J.
dc.contributor.authorSousa, Susana
dc.date.accessioned2021-01-20T09:20:56Z
dc.date.available2022-01-29T01:30:12Z
dc.date.issued2021-04
dc.description.abstractThis study reflects an exploitation of a composite matrix produced by electrospinning of collagen and electrospraying of nanophased hydroxyapatite (nanoHA), for skin regeneration applications. The main goal was to evaluate the effect of nanoHA, as source of localized calcium delivery, on human dermal fibroblasts, keratinocytes, and human mesenchymal stem cells (hMSCs) growth, proliferation, differentiation, and extracellular matrix production. This study revealed that calcium ions provided by nanoHA significantly enhanced cellular growth and proliferation rates and prevented adhesion of pathogenic bacteria strains typically found in human skin flora. Moreover, hMSCs were able to differentiate in both osteogenic and adipogenic lineages. Rat subcutaneous implantation of the membranes also revealed that no adverse reaction occurred. Therefore, the mechanically fit composite membrane presents a great potential to be used either as cell transplantation scaffold for skin wound regeneration or as wound dressing material in plastic surgery, burns treatment or skin diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationRibeiro, N., Sousa, A., Cunha-Reis, C., Oliveira, A. L., Granja, P. L., Monteiro, F. J., Sousa, S. R. (2021). New prospects in skin regeneration and repair using nanophased hydroxyapatite embedded in collagen nanofibers. Nanomedicine: Nanotechnology, Biology and Medicine, 102353pt_PT
dc.identifier.doi10.1016/j.nano.2020.102353pt_PT
dc.identifier.eid85100203422
dc.identifier.issn1549-9634
dc.identifier.pmid33421622
dc.identifier.urihttp://hdl.handle.net/10400.14/31685
dc.identifier.wos000657746000009
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUID/BIM/04293/2013/POCI-01-0145-FEDER-007274pt_PT
dc.relationINTERACTIONS BETWEEN SPARC DERIVED PEPTIDES AND AGGREGATES OF NANOHYDROXYAPATITE AND THEIR EFFECTS ON BONE REGENERATION AND CANCER RELATED BONE METASTASIS
dc.subjectComposite biomaterialpt_PT
dc.subjectSkin wound healingpt_PT
dc.subjectCollagen electrospinningpt_PT
dc.subjectHydroxyapatite electrosprayingpt_PT
dc.subjectCalcium ionspt_PT
dc.titleNew prospects in skin regeneration and repair using nanophased hydroxyapatite embedded in collagen nanofiberspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleINTERACTIONS BETWEEN SPARC DERIVED PEPTIDES AND AGGREGATES OF NANOHYDROXYAPATITE AND THEIR EFFECTS ON BONE REGENERATION AND CANCER RELATED BONE METASTASIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F69686%2F2010/PT
oaire.citation.titleNanomedicine: Nanotechnology, Biology and Medicinept_PT
person.familyNameSousa
person.familyNameOliveira
person.familyNameGranja
person.familyNameMonteiro
person.givenNameAureliana
person.givenNameAna
person.givenNamePedro
person.givenNameFernando
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person.identifier.orcid0000-0002-1361-4605
person.identifier.ridG-6286-2014
person.identifier.ridJ-3404-2013
person.identifier.ridB-1685-2008
person.identifier.scopus-author-id35345790700
person.identifier.scopus-author-id55937245800
person.identifier.scopus-author-id6602391346
person.identifier.scopus-author-id7006030702
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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