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Antimicrobial and antibiofilm activity of chitosan on the oral pathogen Candida albicans

2014Journal article Open access
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dc.contributor.authorCosta, Eduardo
dc.contributor.authorSilva, Sara
dc.contributor.authorTavaria, Freni
dc.contributor.authorPintado, Manuela
dc.date.accessioned2015-04-28T16:30:06Z
dc.date.available2015-04-28T16:30:06Z
dc.date.issued2014
dc.description.abstractOral candidiasis is particularly evident, not only in cancer patients receiving chemotherapy, but also in elderly people with xerostomy. In general, Candida is an opportunistic pathogen, causing infections in immunocompromised people and, in some cases, when the natural microbiota is altered. Chitosan, a natural derivative of chitin, is a polysaccharide that has been proven to possess a broad spectrum of antimicrobial activity that encompasses action against fungi, yeast and bacteria. While recent studies have revealed a significant antibiofilm activity upon several microorganisms, including C. albicans, little is known regarding the impact of chitosan upon the adhesive process or mature biofilms. With that in mind, the purpose of this work was to evaluate, in vitro, the capability of chitosan to inhibit C. albicans growth and biofilm formation. The results obtained showed that chitosan is capable of inhibiting C. albicans planktonic growth (HMW, 1 mg/mL; LMW, 3 mg/mL). Regarding biofilm growth, chitosan inhibited C. albicans adhesion (ca. 95%), biofilm formation (percentages above 90%) and reduced mature biofilms by ca. 65% and dual species biofilms (C. albicans and S. mutans) by ca. 70%. These results display the potential of this molecule to be used as an effective anti-Candida agent capable of acting upon C. albicans infections.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCOSTA, Eduardo …[et al.] - Antimicrobial and Antibiofilm Activity of Chitosan on the Oral Pathogen Candida albicans. Pathogens ISSN 2076-0817. Vol. 3 (2014), p. 908-919por
dc.identifier.doi10.3390/pathogens3040908
dc.identifier.eissn2076-0817
dc.identifier.issn2076-0817
dc.identifier.urihttp://hdl.handle.net/10400.14/17366
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMDPI
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCandidiasispor
dc.subjectCandida albicanspor
dc.subjectChitosanpor
dc.subjectBiofilmpor
dc.subjectAntibiofilmpor
dc.titleAntimicrobial and antibiofilm activity of chitosan on the oral pathogen Candida albicanspor
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PEst-OE%2FEQB%2FLA0016%2F2013/PT
oaire.citation.endPage919
oaire.citation.startPage908
oaire.citation.titlePathogens
oaire.citation.volume3
oaire.fundingStream3599-PPCDT
person.familyNameLeitão Costa
person.familyNameSilva
person.familyNameKekhasharú Tavaria
person.familyNamePintado
person.givenNameEduardo
person.givenNameSara
person.givenNameFreni
person.givenNameMaria Manuela
person.identifierS-3861-2018
person.identifier456608
person.identifier.ciencia-id7214-A61B-3D45
person.identifier.ciencia-id1B15-5DAD-7B27
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0002-2295-5532
person.identifier.orcid0000-0002-0896-9946
person.identifier.orcid0000-0002-6273-6668
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id6602645613
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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