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Natural extracts into chitosan nanocarriers for rosmarinic acid drug delivery

2015-05-01Journal article Open access
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dc.contributor.authorSilva, Sara Baptista da
dc.contributor.authorAmorim, Manuela
dc.contributor.authorFonte, Pedro
dc.contributor.authorMadureira, Raquel
dc.contributor.authorFerreira, Domingos
dc.contributor.authorPintado, Manuela
dc.contributor.authorSarmento, Bruno
dc.date.accessioned2021-07-18T16:30:17Z
dc.date.available2021-07-18T16:30:17Z
dc.date.issued2015-05-01
dc.description.abstractContext: Nanotechnology can be applied to deliver and protect antioxidants in order to control the oxidative stress phenomena in several chronic pathologies. Chitosan (CS) nanoparticles are biodegradable carriers that may protect antioxidants with potent biological activity such as rosmarinic acid (RA) in Salvia officinalis (sage) and Satureja montana (savory) extracts for safe and innovative therapies. Objective: Development and characterization of CS nanoparticles as a stable and protective vehicle to deliver RA for medical applications using natural extracts as sage and savory. Materials and methods: Antioxidant-CS based nanoparticles were prepared by ionic gelation with sodium tripolyphosphate (TPP), at pH 5.8 with a mass ratio of 7:1 (CS:TPP), with a theoretical antioxidant-CS loading of 40-50%. The nanoparticles were then characterized by different methods such as photon correlation spectroscopy, laser Doppler anemometry, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier-transform infrared (FTIR), high-performance liquid chromatographic (HPLC), association efficiency, and antioxidant activity. Results and discussion: Individual and small sizing nanoparticles, around 300 nm, were obtained. SEM confirmed smooth and spherical nanoparticles after freeze-drying. No chemical interactions were found between antioxidants and CS, after encapsulation, by DSC and FTIR. The association efficiency was 51.2% for RA (with 40% loading) and 96.1 and 98.2% for sage and savory nanoparticles, respectively (both with 50% loading). Antioxidant activity values were higher than 0.0348 eq [Asc. Ac.] g/L/g extract and 0.4251 μmol/eq Trolox/g extract. Conclusion: The extracts under study are promising vehicles for RA drug delivery in CS nanocarriers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3109/13880209.2014.935949pt_PT
dc.identifier.eid84924364390
dc.identifier.issn1388-0209
dc.identifier.pmid25489634
dc.identifier.urihttp://hdl.handle.net/10400.14/34161
dc.identifier.wos000351180700004
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantspt_PT
dc.subjectOxidative diseasespt_PT
dc.subjectPharmaceutical nanosystemspt_PT
dc.subjectPolymeric nanoparticlespt_PT
dc.titleNatural extracts into chitosan nanocarriers for rosmarinic acid drug deliverypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage652pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage642pt_PT
oaire.citation.titlePharmaceutical Biologypt_PT
oaire.citation.volume53pt_PT
person.familyNameBaptista da Silva
person.familyNameAmorim
person.familyNameFonte
person.familyNameMadureira
person.familyNameFerreira
person.familyNamePintado
person.familyNameSarmento
person.givenNameSara
person.givenNameMaria Manuela
person.givenNamePedro
person.givenNameRaquel
person.givenNameDomingos
person.givenNameMaria Manuela
person.givenNameBruno
person.identifier404100
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person.identifier.orcid0000-0001-5763-7553
person.identifier.ridL-4327-2014
person.identifier.ridK-3215-2013
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person.identifier.ridF-5696-2013
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person.identifier.scopus-author-id50060987900
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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