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Bacterial degradation of moxifloxacin in the presence of acetate as a bulk substrate

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dc.contributor.authorCarvalho, M. F.
dc.contributor.authorMaia, A. S.
dc.contributor.authorTiritan, M. E.
dc.contributor.authorCastro, P. M. L.
dc.date.accessioned2017-10-13T08:02:31Z
dc.date.available2017-10-13T08:02:31Z
dc.date.issued2016
dc.description.abstractFluoroquinolones constitute a group of emerging pollutants and their occurrence in different environmental compartments is becoming object of increasing public concern due to their ecotoxicological effects and the potential to develop resistant bacteria. This study aimed to investigate the biodegradation of moxifloxacin (MOX), for which studies in the literature are very scarce. An activated sludge (AS) consortium and three bacterial strains able to degrade fluoroaromatic compounds e strains F11, FP1 and S2 e were tested. Biodegradation studies were conducted using acetate as a bulk carbon source. Strain F11 showed the highest biodegradation capacity, being able to completely consume and dehalogenate 7.5 mM of the target antibiotic when daily co-supplemented with acetate present as a readily degradable organic substrate in wastewaters. MOX could be used by strain F11 as a sole nitrogen source but the presence of an external nitrogen source in the culture medium was essential for complete biodegradation. Strain F11 was capable of completely consuming MOX in a range between 2 and 11 mM, although stoichiometric fluoride release was not obtained for the highest tested concentration. The antibacterial activity of residual MOX and of the metabolic products potentially resultant from the biodegradation process was investigated by agar diffusion tests, demonstrating that MOX biodegradation is associated with the elimination of the antibacterial properties of the target antibiotic and of the produced metabolites, which is an important result, as the activity of antibiotics and/or their metabolites in the environment, even at low levels, may lead to the development of resistant bacterial strains. Overall, the results obtained in this study suggest that strain F11 is a promising microorganism for the treatment of waters contaminated with MOX, where it could be used for bioaugmentation/bioremediation purposes. To the best of our knowledge, this is the first study reporting complete removal and dehalogenation of MOX by a single microorganism.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCARVALHO, M. F.; MAIA, A. S.; TIRITAN, M. E.; CASTRO, P. M. L. - Bacterial degradation of moxifloxacin in the presence of acetate as a bulk substrate. Journal of Environmental Management. ISSN 0301-4797. Vol. 168 (2016), p. 219-228pt_PT
dc.identifier.doi10.1016/j.jenvman.2015.12.010pt_PT
dc.identifier.eid84949997039
dc.identifier.pmid26713561
dc.identifier.urihttp://hdl.handle.net/10400.14/23067
dc.identifier.wos000375732100024
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAcademic Press
dc.relationIF/00791/2013pt_PT
dc.relationBIOLOGICAL PRODUCTION OF INDUSTRIALLY RELEVANT FLUOROORGANIC COMPOUNDS
dc.relationFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
dc.subjectMoxifloxacinpt_PT
dc.subjectFluoroquinolonespt_PT
dc.subjectBiodegradationpt_PT
dc.subjectAcetatept_PT
dc.subjectAntimicrobial activitypt_PT
dc.titleBacterial degradation of moxifloxacin in the presence of acetate as a bulk substratept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBIOLOGICAL PRODUCTION OF INDUSTRIALLY RELEVANT FLUOROORGANIC COMPOUNDS
oaire.awardTitleFLUOROPHARMA - Biodegradation and removal of chiral and achiral fluorinated pharmaceuticals from wastewaters
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F44670%2F2008/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F86939%2F2012/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/PEst-OE%2FSAU%2FUI4040%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04423%2F2013/PT
oaire.citation.endPage228
oaire.citation.startPage219
oaire.citation.titleJournal of Environmental Managementpt_PT
oaire.fundingStreamSFRH
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oaire.fundingStream5876
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person.familyNameCarvalho
person.familyNameMaia
person.familyNameTiritan
person.familyNameCastro
person.givenNameM. Fátima
person.givenNameAlexandra S.
person.givenNameMaria Elizabeth
person.givenNamePaula
person.identifier1310409
person.identifier2013444
person.identifier.ciencia-id6913-1464-155B
person.identifier.ciencia-id6A15-F0A3-AEF2
person.identifier.ciencia-idD915-BFC0-FB3A
person.identifier.ciencia-id7C1F-6C72-354A
person.identifier.orcid0000-0002-7181-0540
person.identifier.orcid0000-0002-4167-383X
person.identifier.orcid0000-0003-3320-730X
person.identifier.orcid0000-0001-8841-6606
person.identifier.ridK-9492-2014
person.identifier.ridM-8241-2013
person.identifier.scopus-author-id14038677200
person.identifier.scopus-author-id55332349300
person.identifier.scopus-author-id6602890981
person.identifier.scopus-author-id7102781782
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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