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Cascading reactor-separator sets reduces total processing time for low yield Michaelis-Menten reactions: model predictions

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dc.contributor.authorPaiva, Ana L.
dc.contributor.authorRossum, Diman Van
dc.contributor.authorMalcata, F. Xavier
dc.date.accessioned2011-10-20T16:52:35Z
dc.date.available2011-10-20T16:52:35Z
dc.date.issued1998
dc.description.abstractIntegration of reaction with separation has often been claimed to provide enhanced processing due to alleviation of processing constraints which, like equilibrium limitation or product inhibition, are common in enzyme-catalyzed reactions. In this paper, a mathematical model is developed to assess the effect of cascading sets of enzyme reactors and physical separators (which, when the number of sets tends to infinity, is equivalent to full integration of reaction and separation), when compared with the classical unit operation approach, in terms of total time required to effect reaction and separation for a given overall conversion. The analysis is laid out using several relevant reactional parameters [final conversion of substrate (χf), equilibrium constant (Keq) and dimensionless dissociation constants of substrate and product (K*m,S and K*m,P)] and separational parameters [extent of separation in a single step (ζ) and ratio of time scales for molecular transport and chemical reaction ((Ξ)]. Cascading provides a gain in processing time, up to an optimum at a finite degree of cascading, only for reaction-controlled processes (typified by low ζ, low Ξ, low Keq, low K*m,P, high χf and high K*m,S); hence, full integration is not necessarily the best processing solution. Lengthening of the cascade leads to a decrease in the maximum substrate conversion while permitting higher degrees of product recovery. Read More: http://informahealthcare.com/doi/abs/10.3109/10242429809003199por
dc.identifier.citationPAIVA, ana L. ; ROSSUM, Diman Van; MALCATA, F. Xavier - Cascading reactor-separator sets reduces total processing time for low yield Michaelis-Menten reactions: model predictions. Biocatalysis and Biotransformation.ISSN 1024-2422. Vol. 16, n.º 3 (1998), p. 205–224.por
dc.identifier.doi10.3109/10242429809003199
dc.identifier.urihttp://hdl.handle.net/10400.14/6542
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherInforma Healthcarepor
dc.subjectEnzymatic reactionpor
dc.subjectPhysical separationpor
dc.subjectIntegrationpor
dc.subjectCascadingpor
dc.subjectUnit operationspor
dc.titleCascading reactor-separator sets reduces total processing time for low yield Michaelis-Menten reactions: model predictionspor
dc.typejournal article
dspace.entity.typePublication
person.familyNameMalcata
person.givenNameFrancisco
person.identifier.ciencia-id1B13-38A5-35F5
person.identifier.orcid0000-0003-3073-1659
person.identifier.scopus-author-id7102542478
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublicationa06c00da-0e2f-4434-8ede-4d7b22c0dfe9
relation.isAuthorOfPublication.latestForDiscoverya06c00da-0e2f-4434-8ede-4d7b22c0dfe9

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