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Maternal supplementation with avocado (persea americana mill.) pulp and oil alters reflex maturation, physical development, and offspring memory in rats

2019Journal article Open access
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dc.contributor.authorMelo, Marilia Ferreira Frazão Tavares de
dc.contributor.authorPereira, Diego Elias
dc.contributor.authorMoura, Renally de Lima
dc.contributor.authorSilva, Elisiane Beatriz da
dc.contributor.authorMelo, Flávio Augusto Lyra Tavares de
dc.contributor.authorDias, Celina de Castro Querino
dc.contributor.authorSilva, Maciel da Costa Alves
dc.contributor.authorOliveira, Maria Elieidy Gomes de
dc.contributor.authorViera, Vanessa Bordin
dc.contributor.authorPintado, Maria Manuela Estevez
dc.contributor.authorSantos, Sócrates Golzio dos
dc.contributor.authorSoares, Juliana Késsia Barbosa
dc.date.accessioned2019-01-23T12:33:45Z
dc.date.available2019-01-23T12:33:45Z
dc.date.issued2019
dc.description.abstractAvocado (Persea americana Mill.) is an oleaginous fruit source of fatty acids with high levels of neuroprotective phytocomplexes. The objective of this study was to evaluate the development of reflex and somatic maturation, fatty acid profiles in the brain, and memory in different stages of life in the offspring of dams supplemented with avocado pulp and oil during gestation and lactation. The dams were randomly divided into three groups (n = 15 pups/group), and recieved by gavage supplementation: control group (CG)-distilled water; Avocado Oil (AO)-3,000 mg avocado oil/kg animal weight, and Avocado Pulp (AP)-3,000 mg avocado pulp/kg animal weight. We performed the following tests: Analysis of Somatic Development and Ontogeny of Postnatal Reflex (T0 to T21), the Open Field Habituation Test and the Object Recognition Test (ORT) in the adolescent (T45) and adult (190) phases. The cerebral fatty acids content was evaluated at times T0, T21, T45, and T90. The results were analyzed using the statistical program GraphPad Prism and significant statistics were considered when p < 0.05. Acceleration of reflex maturation and reflex ontogeny was observed in the offspring of AO and AP fed dams, with the results being more pronounced in the pulp fed group (p < 0.05). All groups presented a decrease in the ambulation parameter in the second exposure to the Open Field Habituation Test, at T45 and 190 (p < 0.05). In the ORT, the AO and AP offspring presented memory improvements in the short and long term in the adult and adolescent phases (p < 0.05). The results of the brain fatty acid profiles presented higher polyunsaturated fatty acids (PUFA) content in the AO and AP groups at T21, T45, and 190. The docosahexaenoic fatty acid (DHA) content was higher at T21 (AO and AP), at T45 (AO and AP), and at T90 (AP) (p < 0.05). The arachidonic acid (ARA) content was higher at T45 (AO and AP), and at T90 (AO) (p < 0.05). Maternal supplementation with avocado oil and pulp anticipates reflex maturation and somatic postnatal development, and improves memory during the adolescent and adult phases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMelo, M. F. F. T. de, Pereira, D. E., Moura, R. de L., Silva, E. B. da, Melo, F. A. L. T. de, Dias, C. de C. Q., … Soares, J. K. B. (2019). Maternal Supplementation With Avocado (Persea americana Mill.) Pulp and Oil Alters Reflex Maturation, Physical Development, and Offspring Memory in Rats. Frontiers in Neuroscience, 13. https://doi.org/10.3389/fnins.2019.00009pt_PT
dc.identifier.doi10.3389/fnins.2019.00009pt_PT
dc.identifier.eid85065474723
dc.identifier.issn1662-453X
dc.identifier.pmcPMC6351466
dc.identifier.pmid30728763
dc.identifier.urihttp://hdl.handle.net/10400.14/26741
dc.identifier.wos000456566900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAvocadopt_PT
dc.subjectCerebral fatty acidspt_PT
dc.subjectPostnatal developmentpt_PT
dc.subjectMemorypt_PT
dc.subjectRatspt_PT
dc.titleMaternal supplementation with avocado (persea americana mill.) pulp and oil alters reflex maturation, physical development, and offspring memory in ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Neurosciencept_PT
oaire.citation.volume13
person.familyNamede Castro Querino Dias
person.familyNamePintado
person.givenNameCelina
person.givenNameMaria Manuela
person.identifier456608
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0002-6576-5683
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id7004483898
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication471cd628-e756-426a-916c-86d028977a9f
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc

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