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Propensity for biofilm formation by clinical isolates from urinary tract infections: developing a multifactorial predictive model to improve antibiotherapy

2014Journal article Open access
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dc.contributor.authorAlves, Maria José
dc.contributor.authorBarreira, João C. M.
dc.contributor.authorCarvalho, Inês
dc.contributor.authorTrinta, Luis
dc.contributor.authorPereira, Liliana
dc.contributor.authorFerreira, Isabel C. F. R.
dc.contributor.authorPintado, Manuela
dc.date.accessioned2015-05-12T14:08:23Z
dc.date.available2015-05-12T14:08:23Z
dc.date.issued2014
dc.description.abstractA group of biofilm-producing bacteria isolated from patients with urinary tract infections was evaluated, identifying the main factors contributing to biofilm formation. Among the 156 isolates, 58 (37.2 %) were biofilm producers. The bacterial species (P,0.001), together with patient’s gender (P50.022), were the factors with the highest influence for biofilm production. There was also a strong correlation of catheterization with biofilm formation, despite being less significant (P50.070) than species or gender. In fact, some of the bacteria isolated were biofilm producers in all cases. With regard to resistance profile among bacterial isolates, b-lactam antibiotics presented the highest number of cases/percentages – ampicillin (32/55.2 %), cephalothin (30/ 51.7 %), amoxicillin/clavulanic acid (22/37.9 %) – although the carbapenem group still represented a good therapeutic option (2/3.4 %). Quinolones (nucleic acid synthesis inhibitors) also showed high resistance percentages. Furthermore, biofilm production clearly increases bacterial resistance. Almost half of the biofilm-producing bacteria showed resistance against at least three different groups of antibiotics. Bacterial resistance is often associated with catheterization. Accordingly, intrinsic (age and gender) and extrinsic (hospital unit, bacterial isolate and catheterization) factors were used to build a predictive model, by evaluating the contribution of each factor to biofilm production. In this way, it is possible to anticipate biofilm occurrence immediately after bacterial identification, allowing selection of a more effective antibiotic (among the susceptibility options suggested by the antibiogram) against biofilm-producing bacteria. This approach reduces the putative bacterial resistance during treatment, and the consequent need to adjust antibiotherapypor
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationALVES, Maria José …[et al.] - Propensity for biofilm formation by clinical isolates from urinary tract infections: Developing a multifactorial predictive model to improve antibiotherapy. Journal of Medical Microbiology. ISSN 0022-2615. N.º 63, Part.3 (2014), p. 471-477por
dc.identifier.doi10.1099/jmm.0.071746-0
dc.identifier.issn0022-2615
dc.identifier.urihttp://hdl.handle.net/10400.14/17565
dc.identifier.wosWOS:000338478500018
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherMicrobiology Society
dc.relationStrategic Project - UI 690 - 2011-2012
dc.relationStrategic Project - LA 16 - 2011-2012
dc.relationBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
dc.titlePropensity for biofilm formation by clinical isolates from urinary tract infections: developing a multifactorial predictive model to improve antibiotherapypor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 690 - 2011-2012
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardTitleBIOACTIVE PROPERTIES & CYTOPROTECTIVE POTENTIAL OF NATURAL EXTRACTS/INDIVIDUAL COMPOUNDS: APPLICATION OF SINGLE CELL GEL ELECTROPHORESIS AND OTHER BIOCHEMICAL, CHEMICAL AND ELECTROCHEMICAL ASSAYS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0690%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F72802%2F2010/PT
oaire.citation.endPage477
oaire.citation.issue3
oaire.citation.startPage471
oaire.citation.titleJournal of Medical Microbiology
oaire.citation.volume63
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarreira
person.familyNameFerreira
person.familyNamePintado
person.givenNameJoão
person.givenNameIsabel
person.givenNameMaria Manuela
person.identifier144781
person.identifier456608
person.identifier.ciencia-id9418-CF95-9919
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-1233-0990
person.identifier.orcid0000-0003-4910-4882
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridD-8269-2013
person.identifier.ridE-8500-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id54895546900
person.identifier.scopus-author-id36868826600
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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