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Impact of phlorotannin extracts from fucus vesiculosus on human gut microbiota

2021-06-29Journal article Open access
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dc.contributor.authorCatarino, Marcelo D.
dc.contributor.authorMarçal, Catarina
dc.contributor.authorBonifácio-Lopes, Teresa
dc.contributor.authorCampos, Débora
dc.contributor.authorMateus, Nuno
dc.contributor.authorSilva, Artur M. S.
dc.contributor.authorPintado, Maria Manuela
dc.contributor.authorCardoso, Susana M.
dc.date.accessioned2021-07-20T13:52:57Z
dc.date.available2021-07-20T13:52:57Z
dc.date.issued2021-06-29
dc.description.abstractRecent studies indicate that plant polyphenols could be pointed as potential prebiotic candidates since they may interact with the gut microbiota, stimulating its growth and the production of metabolites. However, little is known about the fate of brown seaweeds’ phlorotannins during their passage throughout the gastrointestinal tract. This work aimed to evaluate the stability and bioaccessibility of Fucus vesiculosus phlorotannins after being submitted to a simulated digestive process, as well as their possible modulatory effects on gut microbiota and short-chain fatty acids production following a fermentation procedure using fecal inoculates to mimic the conditions of the large intestine. The stability of phlorotannins throughout the gastrointestinal tract was reduced, with a bioaccessibility index between 2 and 14%. Moreover, slight alterations in the growth of certain commensal bacteria were noticed, with Enterococcus spp. being the most enhanced group. Likewise, F. vesiculosus phlorotannins displayed striking capacity to enhance the levels of propionate and butyrate, which are two important short-chain fatty acids known for their role in intestinal homeostasis. In summary, this work provides valuable information regarding the behavior of F. vesiculosus phlorotannins along the gastrointestinal tract, presenting clear evidence that these compounds can positively contribute to the maintenance of a healthy gastrointestinal condition.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/md19070375pt_PT
dc.identifier.eid85109486828
dc.identifier.issn1660-3397
dc.identifier.pmcPMC8306378
dc.identifier.pmid34209623
dc.identifier.urihttp://hdl.handle.net/10400.14/34209
dc.identifier.wos000676147200001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBioaccessibilitypt_PT
dc.subjectBrown seaweedspt_PT
dc.subjectGastrointestinal tractpt_PT
dc.subjectGut microbiotapt_PT
dc.subjectPhlorotanninspt_PT
dc.subjectPrebioticspt_PT
dc.subjectShort-chain fatty acidspt_PT
dc.titleImpact of phlorotannin extracts from fucus vesiculosus on human gut microbiotapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.titleMarine Drugspt_PT
oaire.citation.volume19pt_PT
person.familyNameDias Catarino
person.familyNameMarçal
person.familyNameBonifácio
person.familyNameCampos
person.familyNameMateus
person.familyNameSilva
person.familyNamePintado
person.familyNameCardoso
person.givenNameMarcelo
person.givenNameCatarina
person.givenNameTeresa
person.givenNameDébora
person.givenNameNuno
person.givenNameArtur
person.givenNameMaria Manuela
person.givenNameSusana M.
person.identifierD-8675-2016
person.identifier60375
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person.identifier.orcid0000-0002-7882-737X
person.identifier.ridF-3019-2013
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person.identifier.scopus-author-id56581958400
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person.identifier.scopus-author-id6603373064
person.identifier.scopus-author-id7403222204
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id55499269000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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