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Phytochemical composition, antioxidant and antifungal activity of thymus capitatus, a medicinal plant collected from Northern Morocco

2022-05-18Artigo científico Acesso aberto
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dc.contributor.authorBenoutman, Amina
dc.contributor.authorErbiai, El Hadi
dc.contributor.authorEdderdaki, Fatima Zahra
dc.contributor.authorCherif, El Khalil
dc.contributor.authorSaidi, Rabah
dc.contributor.authorLamrani, Zouhaire
dc.contributor.authorPintado, Manuela
dc.contributor.authorPinto, Eugénia
dc.contributor.authorSilva, Joaquim C. G. Esteves da
dc.contributor.authorMaouni, Abdelfettah
dc.date.accessioned2022-06-07T09:46:55Z
dc.date.available2022-06-07T09:46:55Z
dc.date.issued2022-05-18
dc.description.abstractThymus capitatus is a Mediterranean endemic plant commonly known as “Zaïtra” in northern Morocco. As T. capitatus is widely used in traditional medicine and food, this present work aims to investigate the chemical compositions and biological activities of the T. capitatus leaves essential oil (TcLEO), acetonic (TcLAE), and methanolic extract (TcLME). The spectrophotometric determination demonstrated that T. capitatus is a natural source rich in phenolic contents (TPC) and flavonoid contents (TFC) and that TcLME revealed the highest TPC and TFC than TcLAE and TcLEO. The LC-MS analysis of phenolic compounds showed that paraben acid was predominant in both TcLME and TcLAE, followed by cinnamic acid and p-hydroxybenzoic acid. GC-MS analysis of the TcLEO revealed the presence of a total of 10 compounds, which were predominated by carvacrol. The antioxidant activity by ORAC was observed to be significantly higher in TcLEO and TcLAE than in TcLME. All samples used to assess DNA degradation effectively prevented DNA oxidation and, at the same time, had a prooxidant effect. The genotoxicity test showed that the T. capitatus were devoid of any mutagenic activity. Concerning antifungal activity, all samples were able to inhibit the growth of all microorganisms tested at low concentrations. TcLAE showed higher activity than TcLME, and in general, dermatophytes were more susceptible, being Microsporum canis the most sensitive one. Overall, the results obtained from this study confirm the wide uses of T. capitatus. Furthermore, the finding results suggest that the T. capitatus essential oil and extracts can be highly useful for pharmaceutical industries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/antibiotics11050681pt_PT
dc.identifier.eid85130869761
dc.identifier.issn2079-6382
dc.identifier.pmcPMC9137586
dc.identifier.pmid35625325
dc.identifier.urihttp://hdl.handle.net/10400.14/37837
dc.identifier.wos000801715000001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectThymus capitatuspt_PT
dc.subjectBiochemical compositionpt_PT
dc.subjectEssential oilpt_PT
dc.subjectAntioxidant activitypt_PT
dc.subjectGenotoxicity testpt_PT
dc.subjectAntifungal activitypt_PT
dc.titlePhytochemical composition, antioxidant and antifungal activity of thymus capitatus, a medicinal plant collected from Northern Moroccopt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.titleAntibioticspt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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