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Chitosan mouthwash: toxicity and in vivo validation

2014Journal article Restricted access
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dc.contributor.authorCosta, E. M.
dc.contributor.authorSilva, S.
dc.contributor.authorCosta, M. R.
dc.contributor.authorPereira, M.
dc.contributor.authorCampos, D. A.
dc.contributor.authorOdila, J.
dc.contributor.authorMadureira, A. R.
dc.contributor.authorCardelle-Cobas, A.
dc.contributor.authorTavaria, F. K.
dc.contributor.authorRodrigues, A. S.
dc.contributor.authorPintado, M. M.
dc.date.accessioned2015-05-11T17:00:34Z
dc.date.available2015-05-11T17:00:34Z
dc.date.issued2014
dc.description.abstractA previous study showed that a chitosan mouthwash would be a valid alternative to current mouthwashesas it demonstrated, in vitro, significantly higher antibiofilm activity than two commercial mouthwashes.As such, the aim of this work was to verify the safety of the developed product and to validate, in vivo, thebiological activity ascertained in vitro. Chitosan mouthwash safety was evaluated through Ames, MTT andV79 chromosomal aberration assay while antimicrobial activity was evaluated through in vivo assays. Theresults showed that the chitosan mouthwash was safe, presenting lower cytotoxicity than a commercialmouthwash, and that it effectively reduced viable counts of Streptococcus spp. and Enterococcus spp. by ca.5.5 log of CFU. Furthermore, in direct comparison with a commercial mouthwash the chitosan mouthwashpossessed significantly higher antimicrobial activity. The conjunction of these results proves that thechitosan mouthwash is a safe, effective, natural alternative to the existent chemical mouthwashes.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCOSTA, E. M. ...[et al.] - Chitosan mouthwash: Toxicity and in vivo validation. Carbohydrate Polymers. ISSN 0144-8617. Vol. 111 (2014), p. 385–392por
dc.identifier.doi10.1016/j.carbpol.2014.04.046
dc.identifier.issn0144-8617
dc.identifier.urihttp://hdl.handle.net/10400.14/17547
dc.identifier.wosWOS:000340302100044
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier
dc.relationQREN-ADI 3474
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectChitosanpor
dc.subjectMouthwashpor
dc.subjectIn Vivopor
dc.subjectAmespor
dc.subjectMTTpor
dc.subjectAntimicrobialpor
dc.titleChitosan mouthwash: toxicity and in vivo validationpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.citation.endPage392
oaire.citation.startPage385
oaire.citation.titleCarbohydrate Polymers
oaire.citation.volume111
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCosta
person.familyNameSilva
person.familyNameCampos
person.familyNameOdila Pereira
person.familyNameMadureira
person.familyNameCardelle Cobas
person.familyNameKekhasharú Tavaria
person.familyNameRodrigues
person.familyNamePintado
person.givenNameEduardo
person.givenNameSara
person.givenNameDébora
person.givenNameJoana
person.givenNameRaquel
person.givenNameAlejandra
person.givenNameFreni
person.givenNameAntonio Sebastião
person.givenNameMaria Manuela
person.identifier1888852
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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