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Modified cellulose nanocrystals encapsulating cannabigerol: a step forward in controlling intestinal inflammatory disorders

2024-11-12Journal article Open access
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dc.contributor.authorCasanova, Francisca
dc.contributor.authorPereira, Carla F.
dc.contributor.authorRibeiro, Alessandra B.
dc.contributor.authorCastro, Pedro M.
dc.contributor.authorMartins, Eva
dc.contributor.authorFreixo, Ricardo
dc.contributor.authorTavares-Valente, Diana
dc.contributor.authorPimentel, Lígia L.
dc.contributor.authorFontes, Ana L.
dc.contributor.authorRodríguez-Alcalá, Luís M.
dc.contributor.authorFernandes, João C.
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorRamos, Óscar L.
dc.date.accessioned2024-12-12T11:52:16Z
dc.date.available2024-12-12T11:52:16Z
dc.date.issued2024-11-12
dc.description.abstractCannabigerol (CBG) from Cannabis sativa L. is known for its anti-inflammatory, antibacterial, and antioxidant properties, showing potential against intestinal inflammation. However, its lipophilic nature limits its absorption and stability. Researchers have explored cellulose nanocrystals (CNCs) to deliver lipophilic compounds and enhance their biological outcomes. This study investigated the capability of modified CNC with cetyltrimethylammonium bromide (CTAB) to effectively deliver CBG. The encapsulation process’s impact on cytotoxicity, biological activity, and controlled release during digestion was assessed. Results indicated that CNC-CTAB encapsulation significantly reduced CBG’s cytotoxicity on intestinal cells, allowing safer administration of higher doses. The antioxidant and anti-inflammatory properties of the encapsulated CBG were retained, resulting in a decrease in reactive oxygen species and cytokine levels in intestinal cells. Additionally, the system inhibited the growth of the intestinal pathogen Campylobacter jejuni. The study supports using CNC-CTAB as an efficient delivery system to enhance CBG’s potential against intestinal inflammation. Incorporating this system into food matrices could lead to novel functional foods for managing intestinal inflammation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/app142210416pt_PT
dc.identifier.eid85216456095
dc.identifier.issn2076-3417
dc.identifier.urihttp://hdl.handle.net/10400.14/47502
dc.identifier.wos001366749300001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCbgpt_PT
dc.subjectCnc-ctabpt_PT
dc.subjectBiological potentialpt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectDelivery systempt_PT
dc.subjectIntestinal inflammatory disorderspt_PT
dc.titleModified cellulose nanocrystals encapsulating cannabigerol: a step forward in controlling intestinal inflammatory disorderspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue22pt_PT
oaire.citation.titleApplied Sciences-Baselpt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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