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In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems

2019Journal article Restricted access
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dc.contributor.authorPinto, Soraia
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorSarmento, Bruno
dc.date.accessioned2020-01-07T18:14:37Z
dc.date.available2021-01-02T01:30:12Z
dc.date.issued2019
dc.description.abstractIntroduction: Buccal mucosa has been described as an attractive site for local and systemic drug delivery, owing its accessibility, safety, and excellent blood supply. The absorption of drugs through buccal mucosa has been assessed by in vivo, ex vivo and in vitro permeability studies, using animal and cell-based models with close resemblance to the human buccal mucosa. Areas covered: This paper focuses on the current in vivo, ex vivo and in vitro permeability studies to analyze the absorption of compounds of interest through buccal mucosa, as well as their advantages and limitations in the preclinical studies of the drugs absorption profiles. The techniques for preparation and preservation of the animal buccal tissue are also discussed to evaluate their interference in the integrity and permeability of the tissues. Expert opinion: Overall, the permeability studies have been useful to evaluate the drugs absorption and to clarify the mechanism of transport of drugs across human buccal mucosa, as well as to explain the enhancement of permeability provided by certain dosage forms. Currently, several researchers have demonstrated particular interest in ex vivo permeability studies, due to their effectiveness in the evaluation of drug absorption and low costs in the acquisition of buccal mucosa samples.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationPinto, S., Pintado, M. E., Sarmento, B. (2019). In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems. Expert Opinion on Drug Deliverypt_PT
dc.identifier.doi10.1080/17425247.2020.1699913pt_PT
dc.identifier.eid85075977699
dc.identifier.eissn1744-7593
dc.identifier.issn1742-5247
dc.identifier.pmid31786958
dc.identifier.urihttp://hdl.handle.net/10400.14/29107
dc.identifier.wos000500139600001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherTaylor & Francispt_PT
dc.relationNORTE-01-0145-FEDER-000012pt_PT
dc.relationDevelopment of oral strips containing nanoencapsulated bioactive compounds
dc.subjectOral cavitypt_PT
dc.subjectDrug delivery systemspt_PT
dc.subjectPermeability studiespt_PT
dc.subjectAnimal modelspt_PT
dc.subjectEx vivo studiespt_PT
dc.titleIn vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systemspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleDevelopment of oral strips containing nanoencapsulated bioactive compounds
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-NAN%2F3249%2F2014/PT
oaire.citation.titleExpert Opinion on Drug Deliverypt_PT
oaire.fundingStream3599-PPCDT
person.familyNamePintado
person.familyNameSarmento
person.givenNameMaria Manuela
person.givenNameBruno
person.identifier456608
person.identifier152609
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0001-5763-7553
person.identifier.ridF-5696-2013
person.identifier.ridJ-6265-2013
person.identifier.scopus-author-id7004483898
person.identifier.scopus-author-id57194334236
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationba387c7d-27c9-4016-895c-b35597e91ebc
relation.isAuthorOfPublication1df2ac4c-2a82-4f3b-9aea-6f4fb9964752
relation.isAuthorOfPublication.latestForDiscoveryba387c7d-27c9-4016-895c-b35597e91ebc
relation.isProjectOfPublication9681d077-5bd3-4a82-830f-a9a684b77839
relation.isProjectOfPublication.latestForDiscovery9681d077-5bd3-4a82-830f-a9a684b77839

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