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Multi-step subcritical water extracts of fucus vesiculosus l. And codium tomentosum stackhouse: Composition, health-benefits and safety

2021-05Journal article Open access
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dc.contributor.authorSoares, Cristina
dc.contributor.authorPaíga, Paula
dc.contributor.authorMarques, Marta
dc.contributor.authorNeto, Tânia
dc.contributor.authorCarvalho, Ana Paula
dc.contributor.authorPaiva, Alexandre
dc.contributor.authorSimões, Pedro
dc.contributor.authorCosta, Leonor
dc.contributor.authorBernardo, Ana
dc.contributor.authorFernández, Naiara
dc.contributor.authorPinto, Edgar
dc.contributor.authorAlmeida, Agostinho
dc.contributor.authorBronze, Maria Rosário
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.authorGrosso, Clara
dc.date.accessioned2021-06-11T11:14:57Z
dc.date.available2021-06-11T11:14:57Z
dc.date.issued2021-05
dc.description.abstractMental health and active aging are two of the main concerns in the 21st century. To search for new neuroprotective compounds, extracts of Codium tomentosum Stackhouse and Fucus vesiculosus L. were obtained through multi-step (four step) subcritical water extraction using a temperature gradient. The safety assessment of the extracts was performed by screening pharmaceutical compounds and pesticides by UHPLC-MS/MS, and iodine and arsenic levels by ICP-MS. Although the extracts were free of pharmaceutical compounds and pesticides, the presence of arsenic and high iodine contents were found in the first two extraction steps. Thus, the health-benefits were only evaluated for the fractions obtained in steps 3 and 4 from the extraction process. These fractions were tested against five brain enzymes implicated in Alzheimer’s, Parkinson’s, and major depression etiology as well as against reactive oxygen and nitrogen species, having been observed a strong enzyme inhibition and radical scavenging activities for the step 4 fractions from both seaweed species. Regarding the variation of the chemical composition during the extraction, step 1 fractions were the richest in phenolic compounds. With the increase in temperature, Maillard reaction, caramelization and thermo-oxidation occurred, and the resulting products positively affected the antioxidant capacity and the neuroprotective effects.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/pr9050893pt_PT
dc.identifier.eid85106876665
dc.identifier.issn2227-9717
dc.identifier.urihttp://hdl.handle.net/10400.14/33584
dc.identifier.wos000654478400001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBioactivitiespt_PT
dc.subjectEnvironmental contaminantspt_PT
dc.subjectIodinept_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectReactive nitrogen speciespt_PT
dc.subjectReactive oxygen speciespt_PT
dc.subjectSeaweedspt_PT
dc.titleMulti-step subcritical water extracts of fucus vesiculosus l. And codium tomentosum stackhouse: Composition, health-benefits and safetypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5pt_PT
oaire.citation.titleProcessespt_PT
oaire.citation.volume9pt_PT
person.familyNameSoares
person.familyNamePaíga
person.familyNameMARQUES
person.familyNameCarvalho
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person.familyNamePinto
person.familyNameAlmeida
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person.familyNameDelerue-Matos
person.familyNameGrosso
person.givenNameCristina
person.givenNamePaula
person.givenNameMARIA
person.givenNameAna
person.givenNameAlexandre
person.givenNameEdgar
person.givenNameAgostinho
person.givenNameMaria
person.givenNameCristina
person.givenNameAna Clara
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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