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Potential biological properties of lycopene in a self-emulsifying drug delivery system

2023-01Journal article Open access
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dc.contributor.authorBáo, Sônia Nair
dc.contributor.authorMachado, Manuela
dc.contributor.authorSilva, Ana Luisa da
dc.contributor.authorMelo, Adma
dc.contributor.authorCunha, Sara
dc.contributor.authorSousa, Sérgio S.
dc.contributor.authorMalheiro, Ana Rita
dc.contributor.authorFernandes, Rui
dc.contributor.authorLeite, José Roberto S. A.
dc.contributor.authorVasconcelos, Andreanne G.
dc.contributor.authorRelvas, João
dc.contributor.authorPintado, Manuela
dc.date.accessioned2023-01-30T11:16:00Z
dc.date.available2023-01-30T11:16:00Z
dc.date.issued2023-01
dc.description.abstractIn recent years, lycopene has been highlighted due to its antioxidant and anti-inflammatory properties, associated with a beneficial effect on human health. The aim of this study was to advance the studies of antioxidant and anti-inflammatory mechanisms on human keratinocytes cells (HaCaT) of a self-emulsifying drug delivery system (SEDDS) loaded with lycopene purified from red guava (nanoLPG). The characteristics of nanoLPG were a hydrodynamic diameter of 205 nm, a polydispersity index of 0.21 and a zeta potential of −20.57, providing physical stability for the nanosystem. NanoLPG demonstrated antioxidant capacity, as shown using the ORAC methodology, and prevented DNA degradation (DNA agarose). Proinflammatory activity was evaluated by quantifying the cytokines TNF-α, IL-6 and IL-8, with only IL-8 showing a significant increase (p < 0.0001). NanoLPG showed greater inhibition of the tyrosinase and elastase enzymes, involved in the skin aging process, compared to purified lycopene (LPG). In vitro treatment for 24 h with 5.0 µg/mL of nanoLPG did not affect the viability of HaCaT cells. The ultrastructure of HaCaT cells demonstrated the maintenance of morphology. This contrasts with endoplasmic reticulum stresses and autophagic vacuoles when treated with LPG after stimulation or not with LPS. Therefore, the use of lycopene in a nanoemulsion may be beneficial in strategies and products associated with skin health.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/molecules28031219pt_PT
dc.identifier.eid85147956897
dc.identifier.issn1420-3049
dc.identifier.pmcPMC9920511
dc.identifier.pmid36770886
dc.identifier.urihttp://hdl.handle.net/10400.14/40047
dc.identifier.wos000930306800001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationCentre of Biotechnology and Fine Chemistry
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectNanomedicinept_PT
dc.subjectSkin carept_PT
dc.subjectCarotenoidpt_PT
dc.subjectAntioxidantpt_PT
dc.subjectGuava fruitpt_PT
dc.titlePotential biological properties of lycopene in a self-emulsifying drug delivery systempt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Biotechnology and Fine Chemistry
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50016%2F2020/PT
oaire.citation.issue3pt_PT
oaire.citation.titleMoleculespt_PT
oaire.citation.volume28pt_PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication23ce77db-dbe5-4ace-a524-85008a20b8e3
relation.isProjectOfPublication.latestForDiscovery23ce77db-dbe5-4ace-a524-85008a20b8e3

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