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Goat whey ameliorates intestinal inflammation on acetic acid-induced colitis in rats

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dc.contributor.authorAraújo, Daline Fernandes de Souza
dc.contributor.authorGuerra, Gerlane Coelho Bernardo
dc.contributor.authorJúnior, Raimundo Fernandes de Araújo
dc.contributor.authorAntunes de Araújo, Aurigena
dc.contributor.authorAntonino de Assis, Paloma Oliveira
dc.contributor.authorNunes de Medeiros, Ariosvaldo
dc.contributor.authorFormiga de Sousa, Yasmim Regis
dc.contributor.authorPintado, M. E.
dc.contributor.authorGálvez, Julio
dc.contributor.authorQueiroga, Rita de Cássia Ramos do Egypto
dc.date.accessioned2017-10-11T11:07:20Z
dc.date.available2017-10-11T11:07:20Z
dc.date.issued2016
dc.description.abstractComplementary or alternative medicine is of great interest for the treatment of inflammatory bowel disease, with the aim of ameliorating the side effects of the drugs commonly used or improving their efficacy. In this study, we evaluated the ability of goat whey to prevent intestinal inflammation in the experimental model of acetic acid-induced rats and compared it to sulfasalazine. Pretreatment with goat whey (1, 2, and 4g/kg) and sulfasalazine (250mg/kg) on colitic rats improved colonic inflammatory markers, including myeloperoxidase activity, leukotriene B4 levels, as well as the production of proinflammatory cytokines IL-1β and tumor necrosis factor-α. Furthermore, the administration of goat whey significantly reduced the colonic oxidative stress by reducing malondialdehyde levels and increased total glutathione content, a potent antioxidant peptide. The histological evaluation of the colonic specimens from colitic rats confirmed these beneficial effects, as goat whey preserved the colonic tissue, especially in those rats treated with the highest dose of goat whey or with sulfasalazine. The immunohistochemistry analysis of the colonic tissue evaluation also revealed a reduction in the expression of cyclooxygenase-2, inducible nitric oxide synthase, and matrix metalloproteinase-9, together with an increased expression of suppressor of cytokine signaling-1. These results suggest that goat whey exerted a preventive effect against the intestinal damage induced by acetic acid, showing a similar efficacy to that shown by sulfasalazine, therefore making it a potential treatment for human inflammatory bowel disease.pt_PT
dc.description.sponsorshipThe authors are grateful to Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil; process: 400738/2013-9 MEC/MCTI/CNPq/ FAPs nº 71/2013 – PVE/ line 2, process: 473907/2012-7 MCT/ CNPq/ Universal nº14/2012 and process: 403020/2013- 1 MCTI/CT-AGRO/CNPq/nº 39/2013 Line 2) for the financial support for the development of this research, Laboratory Food Chemistry (Universidade Federal da Paraiba, Brazil) for drying goat whey, and to the Junta de Andalucia (AGR-6826 and CTS 164). The Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas (CIBER-EHD) is funded by the Instituto de Salud Carlos III (Granada, Spain).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationARAÚJO, Daline Fernandes de Souza; GUERRA, Gerlane Coelho Bernardo; JÚNIOR, Raimundo Fernandes de Araújo; ARAÚJO, Aurigena Antunes de; ASSIS, Paloma Oliveira Antonino de; MEDEIROS, Ariosvaldo Nunes de; SOUSA, Yasmim Regis Formiga de; PINTADO, M. E.; GÁLVEZ, Julio; QUEIROGA; Rita de Cássia Ramos do Egypto - Goat whey ameliorates intestinal inflammation on acetic acid-induced colitis in rats. Journal of Dairy Science. ISSN 0022-0302. Vol. 99, n.º 12 (2016), p. 9383–9394pt_PT
dc.identifier.doi10.3168/jds.2016-10930pt_PT
dc.identifier.eid84995887436
dc.identifier.pmid27771081
dc.identifier.urihttp://hdl.handle.net/10400.14/22957
dc.identifier.wos000387837500003
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectGoat wheypt_PT
dc.subjectIntestinal inflammationpt_PT
dc.subjectOxidative stresspt_PT
dc.subjectCytokinespt_PT
dc.subjectImmunohistochemicalpt_PT
dc.titleGoat whey ameliorates intestinal inflammation on acetic acid-induced colitis in ratspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage9394
oaire.citation.issue12
oaire.citation.startPage9383
oaire.citation.titleJournal of Dairy Sciencept_PT
oaire.citation.volume99
person.familyNameAraújo
person.familyNameNunes Medeiros
person.familyNamePintado
person.familyNameGalvez
person.givenNameAurigena
person.givenNameAriosvaldo
person.givenNameMaria Manuela
person.givenNameJulio
person.identifier456608
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0001-9264-4695
person.identifier.orcid0000-0002-1997-2649
person.identifier.orcid0000-0002-0760-3184
person.identifier.orcid0000-0001-6876-3782
person.identifier.ridF-5696-2013
person.identifier.ridK-6875-2014
person.identifier.scopus-author-id37022977400
person.identifier.scopus-author-id16506437400
person.identifier.scopus-author-id7004483898
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscovery29e2eb66-4c02-4ac7-b5ae-649a3e9138cd

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