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Optimization of the production of solid Witepsol nanoparticles loadedwith rosmarinic acid

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dc.contributor.authorCampos, Débora A.
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorGomes, Ana Maria
dc.contributor.authorSarmento, Bruno
dc.contributor.authorPintado, Maria Manuela
dc.date.accessioned2015-05-12T14:45:12Z
dc.date.available2015-05-12T14:45:12Z
dc.date.issued2014
dc.description.abstractDuring the last decade there has been a growing interest in the formulation of new food and nutraceu-tical products containing compounds with antioxidant activity. Unfortunately, due to their structure,certain compounds such as polyphenols, in particular rosmarinic acid (RA) are not stable and may inter-act easily with matrices in which they are incorporated. To overcome such limitations, the formulationof loaded polyphenols nanoparticles can offer an efficient solution to protect such compounds. Based onthis rationale, the aim of this study was to prepare solid lipid nanoparticles (SLNs) loaded with RA usinga hot melt ultrasonication method, where Witepsol H15 was used as lipid and Polysorbate 80 (Tween80) as surfactant, following a 32fractional factorial design, resulting in the use of 3 different percentagesof surfactant (viz. 1, 2 and 3%, v/v) and lipid (0.5, 1.0 and 1.5%, w/v). The stability of the nanoparticlessystems were tested during 28 d in aqueous solution stored at refrigeration temperature (ca. 5◦C), track-ing the mean particle size of different formulations by photon correlation spectroscopy. To confirm RAentrapment, thermal analyses of the nanoparticles by DSC and FTIR were performed. The association effi-ciencies percentages (AE%) were determined using HPLC to quantitatively assess the RA in supernatants.Results showed that Witepsol H15 produced nanoparticles with initial mean diameters between 270and 1000 nm, yet over time, a slight increase occurred, but without occurrence of aggregation. The AE%showed a high percentage of encapsulation (ca. 99%), which reveals low polyphenol releases from SLNsthroughout storage time. In general, results showed a successful production of SLNs with properties thatcan be used to food applications.por
dc.description.versioninfo:eu-repo/semantics/publishedVersion
dc.identifier.citationCAMPOSA, Débora A. ...[et al.] - Optimization of the production of solid Witepsol nanoparticles loadedwith rosmarinic acid. Colloids and Surfaces B: Biointerfaces. ISSN 0927-7765. Vol. 115 (2014), p. 109 –117por
dc.identifier.doi10.1016/j.colsurfb.2013.10.035
dc.identifier.urihttp://hdl.handle.net/10400.14/17570
dc.identifier.wosWOS:000335101600015
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevier
dc.relationStrategic Project - LA 16 - 2011-2012
dc.subjectRosmarinicpor
dc.subjectAcidpor
dc.subjectWitepsolpor
dc.subjectSLNspor
dc.subjectOptimizationpor
dc.titleOptimization of the production of solid Witepsol nanoparticles loadedwith rosmarinic acidpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - LA 16 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-ALI%2F117808%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEQB%2FLA0016%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F71391%2F2010/PT
oaire.citation.endPage117
oaire.citation.startPage109
oaire.citation.titleColloids and Surfaces B: Biointerfaces
oaire.citation.volume115
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamSFRH
person.familyNameCampos
person.familyNameMadureira
person.familyNameGomes
person.familyNameSarmento
person.familyNamePintado
person.givenNameDébora
person.givenNameRaquel
person.givenNameAna Maria
person.givenNameBruno
person.givenNameMaria Manuela
person.identifierD-8675-2016
person.identifierM-4659-2013
person.identifier162628
person.identifier152609
person.identifier456608
person.identifier.ciencia-id1A16-FC5B-3468
person.identifier.ciencia-id1C14-25F8-CC07
person.identifier.ciencia-idAA12-BFC1-B2E3
person.identifier.ciencia-idE816-B6B0-06A5
person.identifier.ciencia-id2F13-AAE0-3405
person.identifier.orcid0000-0003-0174-6640
person.identifier.orcid0000-0001-6596-1927
person.identifier.orcid0000-0001-7883-2446
person.identifier.orcid0000-0001-5763-7553
person.identifier.orcid0000-0002-0760-3184
person.identifier.ridM-4659-2013
person.identifier.ridB-9944-2013
person.identifier.ridJ-6265-2013
person.identifier.ridF-5696-2013
person.identifier.scopus-author-id55250923400
person.identifier.scopus-author-id8384097900
person.identifier.scopus-author-id57190668768
person.identifier.scopus-author-id57194334236
person.identifier.scopus-author-id7004483898
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
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