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Clinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angola

2022-10-29Journal article Open access
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dc.contributor.authorSebastião, Cruz S.
dc.contributor.authorCogle, Adis
dc.contributor.authorTeixeira, Alice D’Alva
dc.contributor.authorCândido, Ana Micolo
dc.contributor.authorTchoni, Chissengo
dc.contributor.authorAmorim, Maria João
dc.contributor.authorLoureiro, N’gueza
dc.contributor.authorParimbelli, Paolo
dc.contributor.authorPenha-Gonçalves, Carlos
dc.contributor.authorDemengeot, Jocelyne
dc.contributor.authorSacomboio, Euclides
dc.contributor.authorMendes, Manuela
dc.contributor.authorArrais, Margarete
dc.contributor.authorMorais, Joana
dc.contributor.authorVasconcelos, Jocelyne Neto de
dc.contributor.authorBrito, Miguel
dc.date.accessioned2022-11-30T11:01:06Z
dc.date.available2022-11-30T11:01:06Z
dc.date.issued2022-10-29
dc.description.abstractBackground: Infection due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with clinical features of diverse severity. Few studies investigated the severity and mortality predictors of coronavirus disease 2019 (COVID-19) in Africa. Herein, we investigated the clinical features of severity and mortality among COVID-19 patients in Luanda, Angola. Methods: This multicenter cohort study involved 101 COVID-19 patients, between December 2020 and April 2021, with clinical and laboratory data collected. Analysis was done using independent-sample t-tests and Chi-square tests. The results were deemed significant when p < 0.05. Results: The mean age of patients was 51 years (ranging from 18 to 80 years) and 60.4% were male. Fever (46%), cough (47%), gastrointestinal symptoms (26.7%), and asthenia (26.7%), were the most common symptoms. About 64.4% of the patients presented coexistent disorders, including hypertension (42%), diabetes (17%), and chronic renal diseases (6%). About 23% were non-severe, 77% were severe, and 10% died during hospitalization. Variations in the concentration of neutrophil, urea, creatinine, c-reactive protein, sodium, creatine kinase, and chloride were independently associated with severity and/or mortality (p < 0.05). Conclusion: Several factors contributed to the severity and mortality among COVID-19 patients in Angola. Further studies related to clinical features should be carried out to help clinical decision-making and follow-up of COVID-19 patients in Angola.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/tropicalmed7110338pt_PT
dc.identifier.eid85141748662
dc.identifier.issn2414-6366
dc.identifier.pmcPMC9693333
dc.identifier.pmid36355881
dc.identifier.urihttp://hdl.handle.net/10400.14/39442
dc.identifier.wos000883549900001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAngolapt_PT
dc.subjectClinical featurespt_PT
dc.subjectCOVID-19pt_PT
dc.subjectLuandapt_PT
dc.subjectSARS-CoV-2pt_PT
dc.titleClinical features related to severity and mortality among COVID-19 patients in a pre-vaccine period in Luanda, Angolapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue11pt_PT
oaire.citation.titleTropical Medicine and Infectious Diseasept_PT
oaire.citation.volume7pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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