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Reemergence of yellow fever virus in forest and periurban settings in Brazil

2025-12-15Artigo de investigação Acesso aberto
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dc.contributor.authorAndrade, Valnete das Graças Dantas
dc.contributor.authorAdelino, Talita Émile Ribeiro
dc.contributor.authorFonseca, Vagner
dc.contributor.authorMoreno, Keldenn Melo Farias
dc.contributor.authorTomé, Luiz Marcelo Ribeiro
dc.contributor.authorPereira, Luiz Augusto
dc.contributor.authorLa-Roque, Debora Glenda Lima de
dc.contributor.authorFilippis, Ana Maria Bispo de
dc.contributor.authorRamos, Daniel Garkauskas
dc.contributor.authorRamalho, Dario Brock
dc.contributor.authorFurtado, Kátia Cristina de Lima
dc.contributor.authorBorges, Gleissy Adriane Lima
dc.contributor.authorMartins, Livia Caricio
dc.contributor.authorFrutuoso, Livia C. V.
dc.contributor.authorLamounier, Ludmila Oliveira
dc.contributor.authorGuimarães, Natália Rocha
dc.contributor.authorBarros, Patrícia Miriam Sayuri Sato
dc.contributor.authorAlmeida, Priscila Souza de
dc.contributor.authorSilva, Paulo Eduardo de Souza da
dc.contributor.authorPinheiro, Rodrigo Giesbrecht
dc.contributor.authorStabeli, Rodrigo Guerino
dc.contributor.authorChagas, Shirley Moreira da Silva
dc.contributor.authorPedroso, Sílvia Helena Sousa Pietra
dc.contributor.authorKashima, Simone
dc.contributor.authorPenante, Solange Gonçalves
dc.contributor.authorOliveira, Marília Santini de
dc.contributor.authorSilva, Vinicius Lemes da
dc.contributor.authorVoorhis, Wesley C. Van
dc.contributor.authorHolmes, Edward C.
dc.contributor.authorLourenço, José
dc.contributor.authorIani, Felipe Campos de Melo
dc.contributor.authorJúnior, Alberto Simões Jorge
dc.contributor.authorGiovanetti, Marta
dc.contributor.authorAlcantara, Luiz Carlos Junior
dc.date.accessioned2026-01-30T11:51:57Z
dc.date.available2026-01-30T11:51:57Z
dc.date.issued2025-12-15
dc.description.abstractBackground: Yellow fever virus remains a major public health threat in Brazil, where recent resurgence risks affecting both forest and periurban populations. Understanding viral movement across ecological settings is critical to support early detection and prevent outbreaks. Methods: We performed genomic surveillance in two Brazilian states, a northern Amazon region and a southeastern region, between 2023 and 2025. Human and non-human primate samples were collected across forest, rural, and urban environments. Viral genomes were generated and analyzed using phylogenetic, phylogeographic, and temporal approaches to reconstruct viral transmission patterns. Results: Here, we show evidence of continued yellow fever virus circulation and diversification in distinct ecological settings. We generate 25 genomes from humans and non-human primates, including the first human-derived genomes from the Amazon region. All genomes fall within the South American lineage. We identify one cluster in the Amazon region consistent with undetected viral persistence and reemergence, and a second cluster in the southeast associated with reintroduction followed by sustained local transmission. Conclusions: These findings demonstrate ongoing yellow fever virus activity in Brazil, with forest regions serving as reservoirs for reemergence and periurban areas supporting continued spread. Strengthened genomic and epizootic surveillance is required to detect viral expansion early and inform targeted prevention strategies across Brazil and the Americas.eng
dc.identifier.citationAndrade, V. D. G. D., Adelino, T. É. R., Fonseca, V., & Moreno, K. M. F. et al. (2025). Reemergence of yellow fever virus in forest and periurban settings in Brazil. Communications medicine, 6(1), Article 35. https://doi.org/10.1038/s43856-025-01287-7
dc.identifier.doi10.1038/s43856-025-01287-7
dc.identifier.eid105027987373
dc.identifier.issn2730-664X
dc.identifier.other4d0f6cf6-66f3-4f99-918a-281a4464a3e0
dc.identifier.pmcPMC12820255
dc.identifier.pmid41398472
dc.identifier.urihttp://hdl.handle.net/10400.14/56815
dc.language.isoeng
dc.peerreviewedyes
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleReemergence of yellow fever virus in forest and periurban settings in Brazileng
dc.typeresearch article
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.titleCommunications medicine
oaire.citation.volume6
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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