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Potential wound healing effect of gel based on chicha gum, chitosan, and mauritia flexuosa oil

2022-04-12Journal article Open access
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dc.contributor.authorFerreira, Maria Onaira Gonçalves
dc.contributor.authorRibeiro, Alessandra Braga
dc.contributor.authorRizzo, Marcia S.
dc.contributor.authorOliveira, Antonia Carla de Jesus
dc.contributor.authorOsajima, Josy Anteveli
dc.contributor.authorEstevinho, Leticia M.
dc.contributor.authorSilva-Filho, Edson C.
dc.date.accessioned2022-05-06T14:20:42Z
dc.date.available2022-05-06T14:20:42Z
dc.date.issued2022-04-12
dc.description.abstractWounds are considered a clinically critical issue, and effective treatment will decrease complications, prevent chronic wound formation, and allow rapid healing. The development of products based on naturally occurring materials is an efficient approach to wound healing. Natural polysaccharides can mimic the extracellular matrix and promote cell growth, thus making them attractive for wound healing. In this context, the aim of this work was to produce a gel based on chicha gum, chitosan, and Mauritia flexuosa oil (CGCHO) for wound treatment. TG and DTG analyzed the thermal behavior of the materials, and SEM investigated the surface roughness. The percentages of total phenolic compounds, flavonoids, and antioxidants were determined, presenting a value of 81.811 ± 7.257 µmol gallic acid/g Mauritia flexuosa oil, 57.915 ± 0.305 µmol quercetin/g Mauritia flexuosa oil, and 0.379 mg/mL, respectively. The anti-inflammatory was determined, presenting a value of 10.35 ± 1.46% chicha gum, 16.86 ± 1.00% Mauritia flexuosa oil, 10.17 ± 1.05% CGCHO, and 15.53 ± 0.65% chitosan, respectively. The materials were tested against Gram-negative (Klebsiella pneumoniae) and Gram-positive (Staphylococcus aureus) bacteria and a fungus (Candida albicans). The CGCHO formulation showed better antimicrobial activity against Gram-positive bacteria. In addition, an in vivo wound healing study was also performed. After 21 days of treatment, the epidermal re-epithelialization process was observed. CGCHO showed good thermal stability and roughness that can help in cell growth and promote the tissue healing process. In addition to the good results observed for the antimicrobial, antioxidant, anti-inflammatory activities and providing wound healing, they provided the necessary support for the healing process, thus representing a new approach to the wound healing process.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/biomedicines10040899pt_PT
dc.identifier.eid85129169744
dc.identifier.issn2227-9059
dc.identifier.pmcPMC9025394
dc.identifier.pmid35453649
dc.identifier.urihttp://hdl.handle.net/10400.14/37448
dc.identifier.wos000785213300001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPolysaccharidespt_PT
dc.subjectChicha gumpt_PT
dc.subjectChitosanpt_PT
dc.subjectMauritia flexuosa oilpt_PT
dc.subjectAntimicrobial activitypt_PT
dc.subjectWound healingpt_PT
dc.titlePotential wound healing effect of gel based on chicha gum, chitosan, and mauritia flexuosa oilpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume10pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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