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Use of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterization

2024-02-17Journal article Open access
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dc.contributor.authorPereira, Joana Odila
dc.contributor.authorOliveira, Diana
dc.contributor.authorFaustino, Margarida
dc.contributor.authorVidigal, Susana S. M. P.
dc.contributor.authorPereira, Ana Margarida
dc.contributor.authorFerreira, Carlos M. H.
dc.contributor.authorOliveira, Ana Sofia
dc.contributor.authorDurão, Joana
dc.contributor.authorRodríguez-Alcalá, Luís M.
dc.contributor.authorPintado, Manuela E.
dc.contributor.authorMadureira, Ana Raquel
dc.contributor.authorCarvalho, Ana P.
dc.date.accessioned2024-02-23T11:11:42Z
dc.date.available2024-02-23T11:11:42Z
dc.date.issued2024-02-17
dc.description.abstractSugarcane, a globally cultivated crop constituting nearly 80% of total sugar production, yields residues from harvesting and sugar production known for their renewable bioactive compounds with health-promoting properties. Despite previous studies, the intricate interplay of extracts from diverse sugarcane byproducts and their biological attributes remains underexplored. This study focused on extracting the lipid fraction from a blend of selected sugarcane byproducts (straw, bagasse, and filter cake) using ethanol. The resulting extract underwent comprehensive characterization, including physicochemical analysis (FT-IR, DSC, particle size distribution, and color) and chemical composition assessment (GC-MS). The biological properties were evaluated through antihypertensive (ACE), anticholesterolemic (HMG-CoA reductase), and antidiabetic (alpha-glucosidase and Dipeptidyl Peptidase-IV) assays, alongside in vitro biocompatibility assessments in Caco-2 and Hep G2 cells. The phytochemicals identified, such as β-sitosterol and 1-octacosanol, likely contribute to the extract’s antidiabetic, anticholesterolemic, and antihypertensive potential, given their association with various beneficial bioactivities. The extract exhibited substantial antidiabetic effects, inhibiting α-glucosidase (5–60%) and DPP-IV activity (25–100%), anticholesterolemic potential with HMG-CoA reductase inhibition (11.4–63.2%), and antihypertensive properties through ACE inhibition (24.0–27.3%). These findings lay the groundwork for incorporating these ingredients into the development of food supplements or nutraceuticals, offering potential for preventing and managing metabolic syndrome-associated conditions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.3390/biom14020233pt_PT
dc.identifier.eid85185898891
dc.identifier.issn2218-273X
dc.identifier.pmid38397470
dc.identifier.urihttp://hdl.handle.net/10400.14/44075
dc.identifier.wos001170064100001
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectSugarcanept_PT
dc.subjectLipid extractpt_PT
dc.subjectAntidiabeticpt_PT
dc.subjectAnticholesterolemicpt_PT
dc.subjectAntihypertensionpt_PT
dc.titleUse of various sugarcane byproducts to produce lipid extracts with bioactive properties: physicochemical and biological characterizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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