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Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence

2019Journal article Open access
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dc.contributor.authorPärnänen, Katariina M. M.
dc.contributor.authorNarciso-da-Rocha, Carlos
dc.contributor.authorKneis, David
dc.contributor.authorBerendonk, Thomas U.
dc.contributor.authorCacace, Damiano
dc.contributor.authorDo, Thi Thuy
dc.contributor.authorElpers, Christian
dc.contributor.authorFatta-Kassinos, Despo
dc.contributor.authorHenriques, Isabel
dc.contributor.authorJaeger, Thomas
dc.contributor.authorKarkman, Antti
dc.contributor.authorMartinez, Jose Luis
dc.contributor.authorMichael, Stella G.
dc.contributor.authorMichael-Kordatou, Irene
dc.contributor.authorO’Sullivan, Kristin
dc.contributor.authorRodriguez-Mozaz, Sara
dc.contributor.authorSchwartz, Thomas
dc.contributor.authorSheng, Hongjie
dc.contributor.authorSørum, Henning
dc.contributor.authorStedtfeld, Robert D.
dc.contributor.authorTiedje, James M.
dc.contributor.authorGiustina, Saulo Varela Della
dc.contributor.authorWalsh, Fiona
dc.contributor.authorVaz-Moreira, Ivone
dc.contributor.authorVirta, Marko
dc.contributor.authorManaia, Célia M.
dc.date.accessioned2019-04-12T11:34:20Z
dc.date.available2019-04-12T11:34:20Z
dc.date.issued2019
dc.description.abstractIntegrated antibiotic resistance (AR) surveillance is one of the objectives of the World Health Organization global action plan on antimicrobial resistance. Urban wastewater treatment plants (UWTPs) are among the most important receptors and sources of environmental AR. On the basis of the consistent observation of an increasing north-to-south clinical AR prevalence in Europe, this study compared the influent and final effluent of 12 UWTPs located in seven countries (Portugal, Spain, Ireland, Cyprus, Germany, Finland, and Norway). Using highly parallel quantitative polymerase chain reaction, we analyzed 229 resistance genes and 25 mobile genetic elements. This first trans-Europe surveillance showed that UWTP AR profiles mirror the AR gradient observed in clinics. Antibiotic use, environmental temperature, and UWTP size were important factors related with resistance persistence and spread in the environment. These results highlight the need to implement regular surveillance and control measures, which may need to be appropriate for the geographic regions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPärnänen, K. M. M., Narciso-da-Rocha, C., Kneis, D., Berendonk, T. U., Cacace, D., Do, T. T., … Manaia, C. M. (2019). Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence. Science Advances, 5(3), eaau9124. https://doi.org/10.1126/sciadv.aau9124pt_PT
dc.identifier.doi10.1126/sciadv.aau9124pt_PT
dc.identifier.eid85064041764
dc.identifier.issn2375-2548
dc.identifier.pmcPMC6436925
dc.identifier.pmid30944853
dc.identifier.urihttp://hdl.handle.net/10400.14/27389
dc.identifier.wos000462564300037
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association for the Advancement of Sciencept_PT
dc.relationIF/00492/2013
dc.relationNEW INSIGHTS INTO THE ENVIRONMENTAL ANTIBIOTIC RESISTOME
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleAntibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleNEW INSIGHTS INTO THE ENVIRONMENTAL ANTIBIOTIC RESISTOME
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F87360%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F97131%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/WaterJPI%2F0001%2F2013/PT
oaire.citation.issue3
oaire.citation.titleScience Advancespt_PT
oaire.citation.volume5
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
person.familyNamePärnänen
person.familyNameNarciso-da-Rocha
person.familyNameKneis
person.familyNameCacace
person.familyNameDO
person.familyNameFatta-Kassinos
person.familyNameHenriques
person.familyNameKarkman
person.familyNameMartinez
person.familyNameRodriguez-Mozaz
person.familyNameVaz-Moreira
person.familyNameVirta
person.familyNameManaia
person.givenNameKatariina
person.givenNameCarlos
person.givenNameDavid
person.givenNameDamiano
person.givenNameTHI THUY
person.givenNameDespo
person.givenNameIsabel
person.givenNameAntti
person.givenNameJose Luis
person.givenNameSara
person.givenNameIvone
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person.givenNameCélia
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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